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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2010-4-20
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pubmed:abstractText |
Heterosexual transmission is the primary route by which women acquire human immunodeficiency virus (HIV)/AIDS. Thus, development of woman-controlled topical microbicides for prevention of sexual transmission of HIV is urgently needed. Here we report that 3-hydroxyphthalic anhydride-modified chicken ovalbumin (HP-OVA) exhibits potent antiviral activity against a broad spectrum of human immunodeficiency virus type 1 (HIV-1) isolates with different genotypes and biotypes. Its antiviral activity is correlated with the percentages of the chemically modified and unmodified lysines and arginines in OVA. HP-OVA inhibits HIV-1 fusion and entry through multiple mechanisms of action, including (i) blocking gp120 binding to CD4 and (ii) interfering with gp41 six-helix bundle formation. Because of the widespread availability and established safety profile of OVA, HP-OVA has good potential to be developed as an effective, safe, and affordable microbicide for prevention of HIV sexual transmission.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1098-6596
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1700-11
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pubmed:dateRevised |
2010-11-2
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pubmed:meshHeading |
pubmed-meshheading:20194691-Animals,
pubmed-meshheading:20194691-Anti-HIV Agents,
pubmed-meshheading:20194691-Arginine,
pubmed-meshheading:20194691-CHO Cells,
pubmed-meshheading:20194691-Chickens,
pubmed-meshheading:20194691-Cricetinae,
pubmed-meshheading:20194691-Cricetulus,
pubmed-meshheading:20194691-Drug Design,
pubmed-meshheading:20194691-Epithelial Cells,
pubmed-meshheading:20194691-Female,
pubmed-meshheading:20194691-HIV Envelope Protein gp41,
pubmed-meshheading:20194691-HIV Infections,
pubmed-meshheading:20194691-HIV-1,
pubmed-meshheading:20194691-HIV-2,
pubmed-meshheading:20194691-Humans,
pubmed-meshheading:20194691-Interferon-gamma,
pubmed-meshheading:20194691-Leukocytes, Mononuclear,
pubmed-meshheading:20194691-Lysine,
pubmed-meshheading:20194691-Membrane Fusion,
pubmed-meshheading:20194691-Molecular Weight,
pubmed-meshheading:20194691-Ovalbumin,
pubmed-meshheading:20194691-Phthalic Anhydrides,
pubmed-meshheading:20194691-Protein Structure, Secondary,
pubmed-meshheading:20194691-Sexually Transmitted Diseases, Viral,
pubmed-meshheading:20194691-Simian immunodeficiency virus
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pubmed:year |
2010
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pubmed:articleTitle |
3-hydroxyphthalic anhydride-modified chicken ovalbumin exhibits potent and broad anti-HIV-1 activity: a potential microbicide for preventing sexual transmission of HIV-1.
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pubmed:affiliation |
School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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