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rdf:type |
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lifeskim:mentions |
umls-concept:C0021701,
umls-concept:C0023467,
umls-concept:C0031727,
umls-concept:C0041485,
umls-concept:C0205307,
umls-concept:C0208973,
umls-concept:C0280141,
umls-concept:C0599894,
umls-concept:C0870134,
umls-concept:C1378511,
umls-concept:C1511636,
umls-concept:C1517892,
umls-concept:C1704666
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pubmed:issue |
10
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pubmed:dateCreated |
2010-8-27
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pubmed:abstractText |
Acute myeloid leukemia (AML) is maintained by rare leukemia-initiating cells (L-ICs). FLT3 and/or PI3K pathways are often dysregulated in AML and may be important for L-IC survival. The presence of PI3K pathway intermediate integrin linked kinase (ILK), and FLT3 was confirmed in five L-IC-enriched AML patient samples. Treatment of AML cells with QLT0267, an inhibitor of ILK and FLT3, decreased survival of long-term suspension culture-initiating cells and NOD/SCID mouse L-IC. In contrast, little toxicity toward normal bone marrow progenitors was observed, demonstrating that candidate leukemic stem cells can be eliminated by inhibition of these targets while normal hematopoietic counterparts are spared.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Azo Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Cytarabine,
http://linkedlifedata.com/resource/pubmed/chemical/Daunorubicin,
http://linkedlifedata.com/resource/pubmed/chemical/FLT3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Glycogen Synthase Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/fms-Like Tyrosine Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/integrin-linked kinase
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1873-5835
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1358-65
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:20193963-Adult,
pubmed-meshheading:20193963-Aged,
pubmed-meshheading:20193963-Animals,
pubmed-meshheading:20193963-Azo Compounds,
pubmed-meshheading:20193963-Cells, Cultured,
pubmed-meshheading:20193963-Cytarabine,
pubmed-meshheading:20193963-Daunorubicin,
pubmed-meshheading:20193963-Female,
pubmed-meshheading:20193963-Glycogen Synthase Kinase 3,
pubmed-meshheading:20193963-Humans,
pubmed-meshheading:20193963-Leukemia, Myeloid, Acute,
pubmed-meshheading:20193963-Male,
pubmed-meshheading:20193963-Mice,
pubmed-meshheading:20193963-Mice, Inbred NOD,
pubmed-meshheading:20193963-Middle Aged,
pubmed-meshheading:20193963-Neoplastic Stem Cells,
pubmed-meshheading:20193963-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:20193963-Phosphorylation,
pubmed-meshheading:20193963-Protein Kinase Inhibitors,
pubmed-meshheading:20193963-Protein-Serine-Threonine Kinases,
pubmed-meshheading:20193963-Pyrazoles,
pubmed-meshheading:20193963-RNA, Small Interfering,
pubmed-meshheading:20193963-Stem Cells,
pubmed-meshheading:20193963-fms-Like Tyrosine Kinase 3
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pubmed:year |
2010
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pubmed:articleTitle |
Targeting integrin linked kinase and FMS-like tyrosine kinase-3 is cytotoxic to acute myeloid leukemia stem cells but spares normal progenitors.
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pubmed:affiliation |
Terry Fox Laboratory, British Columbia Cancer Research Centre, Vancouver, BC, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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