Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-3-2
pubmed:abstractText
Accumulating evidence from murine and human studies supports a key role for interleukin-17 (IL-17) and IL-21 in the pathogenesis of inflammatory arthritis. The pathways and molecular mechanisms that underlie the production of IL-17 and IL-21 are being rapidly elucidated. This review focuses on interferon regulatory factor 4 (IRF4), a member of the IRF family of transcription factors, which has emerged as a crucial controller of both IL-17 and IL-21 production. We first outline the complex role of IRF4 in the function of CD4(+) T cells and then discuss recent studies from our laboratory that have revealed a surprising role for components of Rho GTPase-mediated pathways in controlling the activity of IRF4. A better understanding of these novel pathways will hopefully provide new insights into mechanisms responsible for the development of inflammatory arthritis and potentially guide the design of novel therapeutic approaches.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-18173374, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-18275476, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-17911633, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-17277312, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-17201677, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-15894586, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-15879595, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-15931211, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-15749884, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-15657292, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-15459204, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-12871644, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-12633670, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-10770796, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-19383829, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-19144317, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-19062315, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-18602282, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-18563156, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-16906166, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-16849480, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-16572447, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-16470246, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-16412693, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-16200070, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-15790354, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-15684054, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-15535837, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-15023524, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-14555995, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-12816987, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-12648457, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-11961559, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-11441109, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-11080800, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-10864872, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-10681448, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-10601358, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-10382743, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-9551977, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-7797077, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-2523712, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-2125367, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-19362022, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-19234148, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-19119024, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-19098919, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-19088203, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-18941183, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-18836453, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-18836070, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-18679768, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-18454150, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-18039580, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-17581589, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-17569825, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-17404271, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-17373658, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-17038468, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-16990136, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-16147536, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-10490980, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-10022840, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-8999800, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-8824592, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-14600152, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-12857974, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-12651066, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-12500979, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-12101119, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-10706878, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-19414776, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-19273860, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-19342640, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-19188499, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-18469800, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-17994024, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-17393408, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-17414957, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-17363300, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-17121847, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-16616472, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-16551261, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-15886116, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-8657101, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-8777726, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-7541907, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-15040584, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-14634133, http://linkedlifedata.com/resource/pubmed/commentcorrection/20192994-12928373
More...