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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-7-14
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pubmed:abstractText |
Irreversible electroporation (IRE) is a therapeutic technology for the ablation of soft tissues using electrodes to deliver intense but short electric pulses across a cell membrane, creating nanopores that lead to cell death. This phenomenon only affects the cell membrane, leaving the extracellular matrix and sensitive structures intact, making it a promising technique for the treatment many types of tumors. In this paper, we present the first in vivo study to achieve tumor regression using a translatable, clinically relevant single needle electrode for treatment administration. Numerical models of the electric field distribution for the protocol used suggest that a 1000 V/cm field threshold is sufficient to treat a tumor, and that the electric field distribution will slightly decrease if the same protocol were used on a tumor deep seated within a human breast. Tumor regression was observed in 5 out of 7 MDA-MB231 human mammary tumors orthotopically implanted in female Nu/Nu mice, with continued growth in controls.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20191380-11999950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20191380-15123465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20191380-15758807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20191380-15771276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20191380-16684317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20191380-16830945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20191380-16959028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20191380-17668934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20191380-17668936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20191380-17989772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20191380-18376192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20191380-18412934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20191380-19640131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20191380-19757056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20191380-2834285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20191380-2927449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20191380-8356272
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1573-7217
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
123
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
295-301
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pubmed:dateRevised |
2011-7-20
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pubmed:meshHeading |
pubmed-meshheading:20191380-Animals,
pubmed-meshheading:20191380-Cell Line, Tumor,
pubmed-meshheading:20191380-Electrochemotherapy,
pubmed-meshheading:20191380-Electrodes,
pubmed-meshheading:20191380-Female,
pubmed-meshheading:20191380-Humans,
pubmed-meshheading:20191380-Mammary Neoplasms, Experimental,
pubmed-meshheading:20191380-Mice,
pubmed-meshheading:20191380-Mice, Nude,
pubmed-meshheading:20191380-Needles,
pubmed-meshheading:20191380-Xenograft Model Antitumor Assays
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pubmed:year |
2010
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pubmed:articleTitle |
Treatment of breast cancer through the application of irreversible electroporation using a novel minimally invasive single needle electrode.
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pubmed:affiliation |
Bioelectromechanical Systems Lab, Virginia Tech-Wake Forest School of Biomedical Engineering and Sciences, Virginia Tech, 329 ICTAS Building, MC0298, Stranger Street, Blacksburg, VA 24061, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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