Linked Life Data

20190377

Source:http://linkedlifedata.com/resource/pubmed/id/20190377

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-3-1
pubmed:abstractText
There is little doubt that skeletal development and subsequent maintenance of bone mass and morphology during adulthood is greatly influenced by viable muscle function. In this review, we will summarize human observations that support this concept, then focus on models that have enabled (or may enable in the future) insight into the co-dependency of muscle and bone. Specifically, we will summarize data generated with three types of models: 1) spinal cord injury models, 2) transgenic mice with altered muscle function, and 3) experimental models affecting one hindlimb or a single muscle group. In sum, these data clearly support the concept that muscle function is critical for the successful development of the skeleton and is likely to play an important role in mediating bone health through life. The specific signaling pathways by which this interdependency is achieved, however, remain to be clarified.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1108-7161
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
25-34
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
The effect of muscle dysfunction on bone mass and morphology.
pubmed:affiliation
Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, Washington 98104, USA. tgross@u.washington.edu
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural