Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2010-3-22
pubmed:abstractText
Pathogens that cause chronic infections often employ antigenic variation to evade the immune response and persist in the host. In Treponema pallidum (T. pallidum), the causative agent of syphilis, the TprK Ag undergoes variation of seven V regions (V1-V7) by nonreciprocal recombination of silent donor cassettes with the tprK expression site. These V regions are the targets of the host humoral immune response during experimental infection. The present study addresses the causal role of the acquired immune response in the selection of TprK variants in two ways: 1) by investigating TprK variants arising in immunocompetent versus immunosuppressed hosts; and 2) by investigating the effect of prior specific immunization on selection of TprK variants during infection. V region diversity, particularly in V6, accumulates more rapidly in immunocompetent rabbits than in pharmacologically immunosuppressed rabbits (treated with weekly injections of methylprednisolone acetate). In a complementary experiment, rabbits preimmunized with V6 region synthetic peptides had more rapid accumulation of V6 variant treponemes than control rabbits. These studies demonstrate that the host immune response selects against specific TprK epitopes expressed on T. pallidum, resulting in immune selection of new TprK variants during infection, confirming a role for antigenic variation in syphilis.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-10639452, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-11035716, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-12097401, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-14021145, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-1431264, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-14500480, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-14563860, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-15186410, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-15501788, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-15593006, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-156696, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-16109950, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-16495565, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-16923793, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-17030565, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-1727898, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-17521914, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-1885536, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-2252381, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-2648388, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-303968, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-3069867, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-361893, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-3881974, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-4593836, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-4914903, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-4949494, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-5080451, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-589866, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-7014451, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-8423106, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190145-9673251
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1550-6606
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
184
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3822-9
pubmed:dateRevised
2011-7-25
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Antigenic variation in Treponema pallidum: TprK sequence diversity accumulates in response to immune pressure during experimental syphilis.
pubmed:affiliation
Department of Medicine, University of Washington, Seattle, WA 98104, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural