Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-5-17
pubmed:abstractText
The present studies were conducted to investigate the relationship between discriminative stimulus effects of indirectly acting monoaminergic psychostimulants and their ability to increase extracellular levels of dopamine (DA) in the nucleus accumbens (NAcb) shell. First, the behavioral effects of methamphetamine (MA), cocaine (COC), 1-[2-[bis(4-fluorophenyl-)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909), d-amphetamine, and methylphenidate were established in rats trained to discriminate intraperitoneal injections of 0.3 mg/kg MA from saline. In other studies, in vivo microdialysis was used to determine the effects of MA, COC, and GBR 12909 on extracellular DA levels in the NAcb shell. Results show that all drugs produced dose-related and full substitution for the discriminative stimulus effects of 0.3 mg/kg MA. In microdialysis studies, cumulatively administered MA (0.3-3 mg/kg), COC (3-56 mg/kg), and GBR 12909 (3-30 mg/kg) produced dose-dependent increases in DA efflux in the NAcb shell to maxima of approximately 1200 to 1300% of control values. The increase in DA levels produced by MA and COC was rapid and short-lived, whereas the effect of GBR 12909 was slower and longer lasting. Dose-related increases in MA lever selection produced by MA, COC, and GBR 12909 corresponded with graded increases in DA levels in the NAcb shell. Doses of MA, COC, and GBR 12909 that produced full substitution increased DA levels to approximately 200 to 400% of control values. Finally, cumulatively administered MA produced comparable changes in DA levels in both naive and 0.3 mg/kg MA-trained rats. These latter results suggest that sensitization of DA release does not play a prominent role in the discriminative stimulus effects of psychomotor stimulants.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-10234038, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-10633485, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-10657548, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-10663437, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-10760299, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-11002906, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-11007908, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-11120394, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-11401007, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-11513243, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-11690609, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-12023554, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-12445717, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-14735131, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-14755006, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-15064912, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-15464140, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-15681658, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-15765537, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-16014753, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-16817880, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-17031707, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-1715389, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-17255465, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-17258302, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-17825265, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-2432216, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-2623043, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-3130474, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-3668859, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-6794, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-7774666, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-7869099, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-9089847, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-9126740, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-9218282, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-9618419, http://linkedlifedata.com/resource/pubmed/commentcorrection/20190012-9716936
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1521-0103
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
333
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
834-43
pubmed:dateRevised
2011-7-28
pubmed:meshHeading
pubmed-meshheading:20190012-Animals, pubmed-meshheading:20190012-Avoidance Learning, pubmed-meshheading:20190012-Biogenic Monoamines, pubmed-meshheading:20190012-Central Nervous System Stimulants, pubmed-meshheading:20190012-Cocaine, pubmed-meshheading:20190012-Conditioning, Operant, pubmed-meshheading:20190012-Discrimination (Psychology), pubmed-meshheading:20190012-Dopamine, pubmed-meshheading:20190012-Dopamine Uptake Inhibitors, pubmed-meshheading:20190012-Dose-Response Relationship, Drug, pubmed-meshheading:20190012-Extracellular Space, pubmed-meshheading:20190012-Male, pubmed-meshheading:20190012-Methamphetamine, pubmed-meshheading:20190012-Methylphenidate, pubmed-meshheading:20190012-Microdialysis, pubmed-meshheading:20190012-Motor Activity, pubmed-meshheading:20190012-Nucleus Accumbens, pubmed-meshheading:20190012-Piperazines, pubmed-meshheading:20190012-Rats, pubmed-meshheading:20190012-Rats, Sprague-Dawley, pubmed-meshheading:20190012-Reinforcement Schedule
pubmed:year
2010
pubmed:articleTitle
Monoaminergic psychomotor stimulants: discriminative stimulus effects and dopamine efflux.
pubmed:affiliation
Preclinical Pharmacology Laboratory, McLean Hospital/Harvard Medical School, Belmont, Massachusetts 02478, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural