Source:http://linkedlifedata.com/resource/pubmed/id/20189382
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
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| pubmed:dateCreated |
2010-3-22
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| pubmed:abstractText |
Several series of thieno[2-3-b]pyridine analogues were synthesized and screened for inhibitory activity against eukaryotic elongation factor-2 kinase (eEF2-K). Modifications around several regions of the lead molecules were made, with a ring fusion adjacent to the nitrogen on the thienopyridine core being critical for activity. The most active compound 34 shows an IC(50) of 170 nM against eEF2-K in vitro.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
1464-3405
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| pubmed:author | |
| pubmed:copyrightInfo |
2010 Elsevier Ltd. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:day |
1
|
| pubmed:volume |
20
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2283-6
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| pubmed:meshHeading |
pubmed-meshheading:20189382-Cell Line, Tumor,
pubmed-meshheading:20189382-Cell Survival,
pubmed-meshheading:20189382-Elongation Factor 2 Kinase,
pubmed-meshheading:20189382-Enzyme Inhibitors,
pubmed-meshheading:20189382-Humans,
pubmed-meshheading:20189382-Inhibitory Concentration 50,
pubmed-meshheading:20189382-Pyridines,
pubmed-meshheading:20189382-Structure-Activity Relationship
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| pubmed:year |
2010
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| pubmed:articleTitle |
Inhibition of eEF2-K by thieno[2,3-b]pyridine analogues.
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| pubmed:affiliation |
Department of Medicinal Chemistry, Myriad Pharmaceuticals, 305 Chipeta Way, Salt Lake City, UT 84108, United States. jeffrey.lockman@myriadpharma.com
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| pubmed:publicationType |
Journal Article
|