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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-3-10
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pubmed:abstractText |
A series of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives were designed, synthesized, and evaluated for their topoisomerase I and II inhibition and cytotoxic activity against several human cancer cell lines. Compounds 10-19 showed moderate topoisomerase I and II inhibitory activity and 20-29 showed significant topoisomerase II inhibitory activity. Structure-activity relationship study revealed that 4-(5-chlorofuran-2-yl)-2-(thiophen-3-yl) moiety has an important role in displaying topoisomerase II inhibition.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1464-3391
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pubmed:author |
pubmed-author:ChoWon-JeaWJ,
pubmed-author:ChoiHoyoungH,
pubmed-author:ChoiJae HunJH,
pubmed-author:JeongByeong-SeonBS,
pubmed-author:JungMi-JaMJ,
pubmed-author:KarkiRadhaR,
pubmed-author:KwonYoungjooY,
pubmed-author:LeeEung-SeokES,
pubmed-author:NaYounghwaY,
pubmed-author:NamJung MinJM,
pubmed-author:ThapaPritamP,
pubmed-author:YunMinhoM
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pubmed:copyrightInfo |
Copyright 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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|
pubmed:volume |
18
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
2245-54
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:20188578-Antineoplastic Agents,
pubmed-meshheading:20188578-Cell Proliferation,
pubmed-meshheading:20188578-DNA Topoisomerases, Type I,
pubmed-meshheading:20188578-DNA Topoisomerases, Type II,
pubmed-meshheading:20188578-Drug Design,
pubmed-meshheading:20188578-Drug Screening Assays, Antitumor,
pubmed-meshheading:20188578-Enzyme Inhibitors,
pubmed-meshheading:20188578-Humans,
pubmed-meshheading:20188578-Molecular Structure,
pubmed-meshheading:20188578-Pyridines,
pubmed-meshheading:20188578-Stereoisomerism,
pubmed-meshheading:20188578-Structure-Activity Relationship,
pubmed-meshheading:20188578-Topoisomerase I Inhibitors,
pubmed-meshheading:20188578-Topoisomerase II Inhibitors,
pubmed-meshheading:20188578-Tumor Cells, Cultured
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pubmed:year |
2010
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pubmed:articleTitle |
Synthesis of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship.
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pubmed:affiliation |
College of Pharmacy, Yeungnam University, Kyongsan 712-749, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Evaluation Studies
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