Source:http://linkedlifedata.com/resource/pubmed/id/20188570
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2010-3-29
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| pubmed:abstractText |
We investigated the effect of ebselen relative to nimodipine in an animal model of subarachnoid hemorrhage. Thirty Wistar albino rats were divided into 5 groups: G1, no intervention; G2, sham surgery without subarachnoid hemorrhage (SAH); G3, SAH only; G4, SAH plus nimodipine treatment; G5, SAH plus ebselen treatment. For G2 animals, physiological saline (0.9% NaCl) was injected into the cisterna magna. For G3, G4 and G5 animals, SAH was induced by injecting autologous non-heparinized blood into the cisterna magna. One hour after injection, G4 animals received nimodipine at 6-hour intervals and G5 animals received ebselen twice a day for 48 hours. After treatment, brain tissue and blood samples were taken for biochemical and histopathological examination. Mean malonyldialdehyde concentration was significantly higher in G3 than in G1 (p<0.0001), G2 (p=0.01), G4 (p=0.002) and G5 (p=0.014), and significantly higher in G5 than in G1 (p=0.013). Mean superoxide dismutase activity was significantly lower in G4 than in both G1 (p=0.025) and G2 (p=0.02). Mean wall thickness was significantly greater in G3 than in G1 (p<0.0001), G2 (p=0.01), G4 (p<0.0001) and G5 (p<0.0001). Mean wall thickness was also significantly greater in both G1 and G2 than in G4 (p<0.0014 and p<0.0001) and G5 (p<0.0001 and p<0.0001). Mean luminal diameter of the basilar artery was significantly smaller in G3 than in G2 (p=0.02), G4 (p<0.018) and G5 (p<0.001). Our results confirm that ebselen may have neuroprotective effects by acting to prevent vasospasm.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Azoles,
http://linkedlifedata.com/resource/pubmed/chemical/Malondialdehyde,
http://linkedlifedata.com/resource/pubmed/chemical/Nimodipine,
http://linkedlifedata.com/resource/pubmed/chemical/Organoselenium Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase,
http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents,
http://linkedlifedata.com/resource/pubmed/chemical/ebselen
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
1532-2653
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
17
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
608-11
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| pubmed:meshHeading |
pubmed-meshheading:20188570-Analysis of Variance,
pubmed-meshheading:20188570-Animals,
pubmed-meshheading:20188570-Antioxidants,
pubmed-meshheading:20188570-Azoles,
pubmed-meshheading:20188570-Brain,
pubmed-meshheading:20188570-Drug Administration Schedule,
pubmed-meshheading:20188570-Female,
pubmed-meshheading:20188570-Injections, Intraventricular,
pubmed-meshheading:20188570-Malondialdehyde,
pubmed-meshheading:20188570-Nimodipine,
pubmed-meshheading:20188570-Organoselenium Compounds,
pubmed-meshheading:20188570-Oxidative Stress,
pubmed-meshheading:20188570-Rats,
pubmed-meshheading:20188570-Rats, Wistar,
pubmed-meshheading:20188570-Subarachnoid Hemorrhage,
pubmed-meshheading:20188570-Superoxide Dismutase,
pubmed-meshheading:20188570-Vasodilator Agents,
pubmed-meshheading:20188570-Vasospasm, Intracranial
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| pubmed:year |
2010
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| pubmed:articleTitle |
Effects of ebselen versus nimodipine on cerebral vasospasm subsequent to experimental subarachnoid hemorrhage in rats.
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| pubmed:affiliation |
Department of Neurosurgery, School of Medicine, Zonguldak Karaelmas University, Esenkoy, Kozlu, Zonguldak 67600, Turkey. drsanser@yahoo.com <drsanser@yahoo.com>
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| pubmed:publicationType |
Journal Article
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