Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1991-5-28
|
| pubmed:abstractText |
A novel leukemic cell line with an 8;21 chromosome translocation, designated as Kasumi-1, was established from the peripheral blood of a 7-year-old boy suffering from acute myeloid leukemia (AML). The Kasumi-1 cells were positive for myeloperoxidase showing a morphology of myeloid maturation. The response in proliferation assay was observed in the culture with interleukin-3 (IL-3), IL-6, granulocyte colony-stimulating factor (G-CSF), and granulocytemacrophage CSF (GM-CSF), but not with IL-1 or IL-5. Neither granulocytic nor eosinophilic maturation was observed in the liquid culture by the addition of dimethyl sulfoxide, G-CSF, or IL-5, respectively. In contrast, induction of macrophagelike cells was seen by the addition of phorbol ester. This is the first report of a human AML cell line with t(8;21) that has characteristics of myeloid and macrophage lineages. The cell line could be a useful tool for elucidating the pathophysiology of AML with t(8;21).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0006-4971
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
77
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2031-6
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2018839-Antigens, CD,
pubmed-meshheading:2018839-Cell Differentiation,
pubmed-meshheading:2018839-Cell Division,
pubmed-meshheading:2018839-Cell Nucleus,
pubmed-meshheading:2018839-Child,
pubmed-meshheading:2018839-Chromosomes, Human, Pair 21,
pubmed-meshheading:2018839-Chromosomes, Human, Pair 8,
pubmed-meshheading:2018839-Cytoplasm,
pubmed-meshheading:2018839-Growth Substances,
pubmed-meshheading:2018839-Humans,
pubmed-meshheading:2018839-Immunophenotyping,
pubmed-meshheading:2018839-Karyotyping,
pubmed-meshheading:2018839-Leukemia, Myeloid, Acute,
pubmed-meshheading:2018839-Male,
pubmed-meshheading:2018839-Nucleic Acid Hybridization,
pubmed-meshheading:2018839-Recombinant Proteins,
pubmed-meshheading:2018839-Translocation, Genetic,
pubmed-meshheading:2018839-Tumor Cells, Cultured
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Establishment of a human acute myeloid leukemia cell line (Kasumi-1) with 8;21 chromosome translocation.
|
| pubmed:affiliation |
Department of Hematology, Hiroshima University, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|