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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-3-3
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pubmed:abstractText |
We investigated the influence of the temporal resolution of dynamic contrast-enhanced MRI data on pharmacokinetic parameter estimation. Dynamic Gd-DTPA (Gadolinium-diethylene triamine pentaacetic acid) enhanced MRI data of implanted prostate tumors on rat hind limb were acquired at 4.7 T, with a temporal resolution of approximately 5 sec. The data were subsequently downsampled to temporal resolutions in the range of 15 sec to 85 sec, using a strategy that involves a recombination of k-space data. A basic two-compartment model was fit to the contrast agent uptake curves. The results demonstrated that as temporal resolution decreases, the volume transfer constant (K(trans)) is progressively underestimated (approximately 4% to approximately 25%), and the fractional extravascular extracellular space (v(e)) is progressively overestimated (approximately 1% to approximately 10%). The proposed downsampling strategy simulates the influence of temporal resolution more realistically than simply downsampling by removing samples.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187187-10398984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187187-10508281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187187-11870848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187187-15004789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187187-15221817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187187-15503330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187187-16118161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187187-17222712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187187-17763350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187187-18001891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187187-18389253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187187-18429040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187187-18777534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187187-9786152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187187-9839990
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1522-2594
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2010 Wiley-Liss, Inc.
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pubmed:issnType |
Electronic
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
811-6
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pubmed:dateRevised |
2011-7-28
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pubmed:meshHeading |
pubmed-meshheading:20187187-Animals,
pubmed-meshheading:20187187-Computer Simulation,
pubmed-meshheading:20187187-Contrast Media,
pubmed-meshheading:20187187-Gadolinium DTPA,
pubmed-meshheading:20187187-Humans,
pubmed-meshheading:20187187-Image Enhancement,
pubmed-meshheading:20187187-Information Storage and Retrieval,
pubmed-meshheading:20187187-Metabolic Clearance Rate,
pubmed-meshheading:20187187-Models, Biological,
pubmed-meshheading:20187187-Rats,
pubmed-meshheading:20187187-Reproducibility of Results,
pubmed-meshheading:20187187-Sensitivity and Specificity,
pubmed-meshheading:20187187-Time Factors
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pubmed:year |
2010
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pubmed:articleTitle |
The influence of temporal resolution in determining pharmacokinetic parameters from DCE-MRI data.
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pubmed:affiliation |
Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands. m.heisen@tue.nl
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pubmed:publicationType |
Journal Article,
Evaluation Studies
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