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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2010-5-4
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pubmed:abstractText |
DC are professional APC that instruct T cells during the inflammatory course of EAE. We have previously shown that MAPK3 (Erk1) is important for the induction of T-cell anergy. Our goal was to determine the influence of MAPK3 on the capacity of DC to arm T-cell responses in autoimmunity. We report that DC from Mapk3(-/-) mice have a significantly higher membrane expression of CD86 and MHC-II and--when loaded with the myelin oligodendrocyte glycoprotein--show a superior capacity to prime naïve T cells towards an inflammatory phenotype than Mapk3(+/+) DC. Nonetheless and as previously described, Mapk3(-/-) mice were only slightly but not significantly more susceptible to myelin oligodendrocyte glycoprotein-induced EAE than WT littermate mice. However, Mapk3(+/+) mice engrafted with Mapk3(-/-) BM (KO-->WT) developed a severe form of EAE, in direct contrast to WT-->KO mice, which were even less sick than control WT-->WT mice. An infiltration of DC and accumulation of Th17 cells was also observed in the CNS of KO-->WT mice. Therefore, triggering of MAPK3 in the periphery might be a therapeutic option for the treatment of neuroinflammation since absence of this kinase in the immune system leads to severe EAE.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD86,
http://linkedlifedata.com/resource/pubmed/chemical/Cd86 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/OVA 323-339,
http://linkedlifedata.com/resource/pubmed/chemical/Ovalbumin,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/myelin oligodendrocyte...
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1521-4141
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pubmed:author |
pubmed-author:BendixIvoI,
pubmed-author:GlezevaNadezhdaN,
pubmed-author:HansenWiebkeW,
pubmed-author:LeuenbergerTinaT,
pubmed-author:LoddenkemperChristophC,
pubmed-author:MüllerYasminY,
pubmed-author:PfuellerCaspar FCF,
pubmed-author:ProzorovskiTimourT,
pubmed-author:Schulze TopphoffUlfU,
pubmed-author:SiffrinVolkerV,
pubmed-author:WaicziesSoniaS,
pubmed-author:ZippFraukeF
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pubmed:issnType |
Electronic
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1486-95
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pubmed:dateRevised |
2010-6-23
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pubmed:meshHeading |
pubmed-meshheading:20186879-Animals,
pubmed-meshheading:20186879-Antigens, CD86,
pubmed-meshheading:20186879-Autoimmunity,
pubmed-meshheading:20186879-Cytokines,
pubmed-meshheading:20186879-Dendritic Cells,
pubmed-meshheading:20186879-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:20186879-Glycoproteins,
pubmed-meshheading:20186879-Histocompatibility Antigens Class II,
pubmed-meshheading:20186879-MAP Kinase Signaling System,
pubmed-meshheading:20186879-Mice,
pubmed-meshheading:20186879-Mice, Inbred C57BL,
pubmed-meshheading:20186879-Mice, Transgenic,
pubmed-meshheading:20186879-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:20186879-Ovalbumin,
pubmed-meshheading:20186879-Peptide Fragments,
pubmed-meshheading:20186879-Radiation Chimera,
pubmed-meshheading:20186879-Specific Pathogen-Free Organisms,
pubmed-meshheading:20186879-T-Cell Antigen Receptor Specificity,
pubmed-meshheading:20186879-T-Lymphocyte Subsets
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pubmed:year |
2010
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pubmed:articleTitle |
MAPK3 deficiency drives autoimmunity via DC arming.
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pubmed:affiliation |
Max Delbruck Center for Molecular Medicine, Berlin, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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