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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2010-4-29
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pubmed:abstractText |
The insulinotropic action of the incretin glucose-dependent insulinotropic polypeptide (GIP) is impaired in type 2 diabetes, while the effect of glucagon-like peptide-1 (GLP-1) is preserved. To evaluate the role of impaired GIP function in glucose homeostasis and development of the endocrine pancreas in a large animal model, we generated transgenic pigs expressing a dominant-negative GIP receptor (GIPR(dn)) in pancreatic islets.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20185813-10499546,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/20185813-8672872
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1939-327X
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pubmed:author |
pubmed-author:AmselgruberWernerW,
pubmed-author:ChodnevskajaIrinaI,
pubmed-author:FehlingsChristianeC,
pubmed-author:GökeBurkhardB,
pubmed-author:HerbachNadjaN,
pubmed-author:HofmannAndreasA,
pubmed-author:KesslerBarbaraB,
pubmed-author:MoskalenkoVasiliyV,
pubmed-author:PfeiferAlexanderA,
pubmed-author:RennerSimoneS,
pubmed-author:UlrichsKarinK,
pubmed-author:WankeRüdigerR,
pubmed-author:WolfEckhardE,
pubmed-author:von WaldthausenDagmar CDC
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pubmed:issnType |
Electronic
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1228-38
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20185813-Animals,
pubmed-meshheading:20185813-Animals, Genetically Modified,
pubmed-meshheading:20185813-Glucagon-Like Peptide 1,
pubmed-meshheading:20185813-Glucose,
pubmed-meshheading:20185813-Glucose Intolerance,
pubmed-meshheading:20185813-Glucose Tolerance Test,
pubmed-meshheading:20185813-Immunohistochemistry,
pubmed-meshheading:20185813-Insulin,
pubmed-meshheading:20185813-Insulin-Secreting Cells,
pubmed-meshheading:20185813-Receptors, Glucagon,
pubmed-meshheading:20185813-Swine
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pubmed:year |
2010
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pubmed:articleTitle |
Glucose intolerance and reduced proliferation of pancreatic beta-cells in transgenic pigs with impaired glucose-dependent insulinotropic polypeptide function.
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pubmed:affiliation |
Chair for Molecular Animal Breeding and Biotechnology and Laboratory for Functional Genome Analysis, Gene Center, Ludwig Maximilians University (LMU) Munich, Munich, Germany.
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pubmed:publicationType |
Journal Article
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