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rdf:type |
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lifeskim:mentions |
umls-concept:C0007600,
umls-concept:C0017262,
umls-concept:C0022614,
umls-concept:C0023516,
umls-concept:C0040648,
umls-concept:C0085828,
umls-concept:C0086418,
umls-concept:C0108747,
umls-concept:C0185117,
umls-concept:C0521447,
umls-concept:C1136310,
umls-concept:C1366562,
umls-concept:C1414555,
umls-concept:C1819461,
umls-concept:C2603343,
umls-concept:C2911684
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pubmed:issue |
3
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pubmed:dateCreated |
2010-2-26
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pubmed:abstractText |
Recent data indicate that ketamine exerts antiinflammatory actions. However, little is known about the signaling mechanisms involved in ketamine-induced immune modulation. In this study, we investigated the effects of ketamine on lipopolysaccharide-induced activation of transcription factors activator protein 1 (AP-1) and nuclear factor-kappaB (NF-kappaB) in human leukocyte-like cell lines and in human blood neutrophils.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD11b,
http://linkedlifedata.com/resource/pubmed/chemical/FCGR3B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/GPI-Linked Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/IL8 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/ITGAM protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-8,
http://linkedlifedata.com/resource/pubmed/chemical/Ketamine,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgG,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, mu,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor AP-1,
http://linkedlifedata.com/resource/pubmed/chemical/lipopolysaccharide, E. coli 026-B6
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1526-7598
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
110
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
934-41
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:20185670-Adult,
pubmed-meshheading:20185670-Anti-Inflammatory Agents,
pubmed-meshheading:20185670-Antigens, CD11b,
pubmed-meshheading:20185670-Dose-Response Relationship, Drug,
pubmed-meshheading:20185670-Down-Regulation,
pubmed-meshheading:20185670-Electrophoretic Mobility Shift Assay,
pubmed-meshheading:20185670-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:20185670-Flow Cytometry,
pubmed-meshheading:20185670-GPI-Linked Proteins,
pubmed-meshheading:20185670-HL-60 Cells,
pubmed-meshheading:20185670-Humans,
pubmed-meshheading:20185670-Interleukin-8,
pubmed-meshheading:20185670-Ketamine,
pubmed-meshheading:20185670-Leukocytes,
pubmed-meshheading:20185670-Lipopolysaccharides,
pubmed-meshheading:20185670-Male,
pubmed-meshheading:20185670-NF-kappa B,
pubmed-meshheading:20185670-Neutrophils,
pubmed-meshheading:20185670-Receptors, IgG,
pubmed-meshheading:20185670-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:20185670-Receptors, Opioid, mu,
pubmed-meshheading:20185670-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20185670-Signal Transduction,
pubmed-meshheading:20185670-Transcription Factor AP-1,
pubmed-meshheading:20185670-U937 Cells,
pubmed-meshheading:20185670-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Ketamine inhibits transcription factors activator protein 1 and nuclear factor-kappaB, interleukin-8 production, as well as CD11b and CD16 expression: studies in human leukocytes and leukocytic cell lines.
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pubmed:affiliation |
School of Clinical Science, University of Liverpool, The Duncan Building, Daulby St., Liverpool L69 3GA, UK. i.welters@chiru.med.uni-giessen.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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