Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2010-2-26
pubmed:abstractText
The aim of this study was to examine the relative value and the influence of the association of 4 cardiac magnetic resonance (CMR) viability indexes for predicting segmental functional recovery after optimal pharmacologic therapies and early percutaneous coronary intervention in acute myocardial infarction (AMI). CMR has been shown to predict functional recovery after AMI. The relative predictive value of CMR viability indexes remains disputed and has not been described in AMI reperfused within the first 12 hours. Sixty-nine patients with a first reperfused (<12 hours) Thrombolysis In Myocardial Infarction grade 3 AMI (61 men, 57.6 +/- 12.6 years) were studied on day 5 +/- 2. Low-dose (10 microg/kg/min) dobutamine response (DOB), microvascular obstruction (MVO), relative delayed enhancement extent (DE), and transmural DE pattern (TMDE) were assessed in each of the 17 left ventricular segments. Segmental functional outcome was assessed by CMR at 3 months. Logistic regression and Bayesian probabilities evaluated the association between viability indexes and functional segmental outcome. At rest, 27% of segments (314 of 1,173) were dysfunctional of which 53% (165 of 314) recovered at follow-up. Odd ratios for dobutamine response, MVO, DE, and TMDE were 15.8, 5.9, 2.6, and 2.5 respectively. The probability of segmental recovery was 0.84 when dobutamine response was positive and increased successively to 0.91 when adding MVO absence, 0.94 when adding TMDE absence, and 0.97 when adding DE absence. In conclusion, contractile response to low-dose dobutamine is the best predictive factor of segmental recovery after Thrombolysis In Myocardial Infarction grade 3 early reperfused AMI. Its value is further increased by other CMR viability indexes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1879-1913
pubmed:author
pubmed:copyrightInfo
Copyright 2010 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
105
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
598-604
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:20185003-Adult, pubmed-meshheading:20185003-Aged, pubmed-meshheading:20185003-Aged, 80 and over, pubmed-meshheading:20185003-Angioplasty, Balloon, Coronary, pubmed-meshheading:20185003-Cardiotonic Agents, pubmed-meshheading:20185003-Cohort Studies, pubmed-meshheading:20185003-Dobutamine, pubmed-meshheading:20185003-Female, pubmed-meshheading:20185003-Humans, pubmed-meshheading:20185003-Magnetic Resonance Imaging, pubmed-meshheading:20185003-Male, pubmed-meshheading:20185003-Middle Aged, pubmed-meshheading:20185003-Myocardial Infarction, pubmed-meshheading:20185003-Predictive Value of Tests, pubmed-meshheading:20185003-Recovery of Function, pubmed-meshheading:20185003-Severity of Illness Index, pubmed-meshheading:20185003-Stroke Volume, pubmed-meshheading:20185003-Tissue Survival, pubmed-meshheading:20185003-Treatment Outcome
pubmed:year
2010
pubmed:articleTitle
Comparative analysis of cardiac magnetic resonance viability indexes to predict functional recovery after successful percutaneous coronary intervention in acute myocardial infarction.
pubmed:affiliation
Soins Intensifs Cardiologiques--Plateau de Cardiologie Interventionnelle, France.
pubmed:publicationType
Journal Article, Comparative Study, Randomized Controlled Trial