2018470

Source:http://linkedlifedata.com/resource/pubmed/id/2018470

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0021641, umls-concept:C0031586, umls-concept:C0178666, umls-concept:C0206131, umls-concept:C1176299, umls-concept:C1280500, umls-concept:C1704711
pubmed:dateCreated	1991-5-22
pubmed:abstractText	We examined the effects of the phorbol ester phorbol 12-myristate 13-acetate (PMA) on the rate of hexose transport into 3T3-L1 adipocytes. Exposure of adipocytes to PMA (1 microM) for 60 min results in a 1.7-2.5-fold increase in the rate of hexose transport. This effect was mediated by translocation of two isoforms of glucose transporters to the plasma membrane, as determined by labelling in situ, photoaffinity labelling with a membrane-impermeant glucose analogue, and by immunoblotting of subcellular fractions. The PMA-induced stimulation of both transport and transporter translocation was substantially less than that induced by insulin in this cell line; the PMA-induced increase in plasma-membrane GLUT 1 and GLUT 4 transporter isoforms was only about 40% and 10% respectively of that induced by insulin. We suggest that the stimulation of transport by insulin and PMA occurs via different mechanisms, which is manifested by the ability of insulin to induce a much greater increase in the plasma-membrane content of GLUT 4 compared with the phorbol ester.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/DK 25336
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/2018470-2199443, http://linkedlifedata.com/resource/pubmed/commentcorrection/2018470-2390055, http://linkedlifedata.com/resource/pubmed/commentcorrection/2018470-2643384, http://linkedlifedata.com/resource/pubmed/commentcorrection/2018470-2645527, http://linkedlifedata.com/resource/pubmed/commentcorrection/2018470-2649253, http://linkedlifedata.com/resource/pubmed/commentcorrection/2018470-2649883, http://linkedlifedata.com/resource/pubmed/commentcorrection/2018470-2654938, http://linkedlifedata.com/resource/pubmed/commentcorrection/2018470-2656669, http://linkedlifedata.com/resource/pubmed/commentcorrection/2018470-2803236, http://linkedlifedata.com/resource/pubmed/commentcorrection/2018470-2917998, http://linkedlifedata.com/resource/pubmed/commentcorrection/2018470-2923892, http://linkedlifedata.com/resource/pubmed/commentcorrection/2018470-3048418, http://linkedlifedata.com/resource/pubmed/commentcorrection/2018470-3058203, http://linkedlifedata.com/resource/pubmed/commentcorrection/2018470-3085730, http://linkedlifedata.com/resource/pubmed/commentcorrection/2018470-3103217, http://linkedlifedata.com/resource/pubmed/commentcorrection/2018470-3105598, http://linkedlifedata.com/resource/pubmed/commentcorrection/2018470-3137219, http://linkedlifedata.com/resource/pubmed/commentcorrection/2018470-3276714, http://linkedlifedata.com/resource/pubmed/commentcorrection/2018470-3281656, http://linkedlifedata.com/resource/pubmed/commentcorrection/2018470-3285221, http://linkedlifedata.com/resource/pubmed/commentcorrection/2018470-3301853, http://linkedlifedata.com/resource/pubmed/commentcorrection/2018470-3511974, http://linkedlifedata.com/resource/pubmed/commentcorrection/2018470-3536929, http://linkedlifedata.com/resource/pubmed/commentcorrection/2018470-3597413, http://linkedlifedata.com/resource/pubmed/commentcorrection/2018470-3882699, http://linkedlifedata.com/resource/pubmed/commentcorrection/2018470-3902816, http://linkedlifedata.com/resource/pubmed/commentcorrection/2018470-4773858, http://linkedlifedata.com/resource/pubmed/commentcorrection/2018470-603028, http://linkedlifedata.com/resource/pubmed/commentcorrection/2018470-6771756, http://linkedlifedata.com/resource/pubmed/commentcorrection/2018470-6989818
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/2984726R
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Deoxyglucose, http://linkedlifedata.com/resource/pubmed/chemical/Glucose, http://linkedlifedata.com/resource/pubmed/chemical/Insulin, http://linkedlifedata.com/resource/pubmed/chemical/Monosaccharide Transport Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Phorbol Esters, http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C, http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate, http://linkedlifedata.com/resource/pubmed/chemical/phorbol-12,13-didecanoate
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	0264-6021
pubmed:author	pubmed-author:CalderheadD MDM, pubmed-author:GibbsE MEM, pubmed-author:GouldG WGW, pubmed-author:HolmanG DGD
pubmed:issnType	Print
pubmed:day	1
pubmed:volume	275 ( Pt 1)
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	145-50
pubmed:dateRevised	2011-11-17
pubmed:meshHeading	pubmed-meshheading:2018470-Adipose Tissue, pubmed-meshheading:2018470-Biological Transport, pubmed-meshheading:2018470-Deoxyglucose, pubmed-meshheading:2018470-Glucose, pubmed-meshheading:2018470-Humans, pubmed-meshheading:2018470-Insulin, pubmed-meshheading:2018470-Kinetics, pubmed-meshheading:2018470-Monosaccharide Transport Proteins, pubmed-meshheading:2018470-Phorbol Esters, pubmed-meshheading:2018470-Phosphorylation, pubmed-meshheading:2018470-Protein Kinase C, pubmed-meshheading:2018470-Tetradecanoylphorbol Acetate
pubmed:year	1991
pubmed:articleTitle	Phorbol ester only partially mimics the effects of insulin on glucose transport and glucose-transporter distribution in 3T3-L1 adipocytes.
pubmed:affiliation	Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03756.
pubmed:publicationType	Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't