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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2010-2-26
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pubmed:abstractText |
Our objectives were to analyse carbohydrate metabolism in a series of ALS patients and to examine potential association with parameters of lipid metabolism and clinical features. Glucose tolerance was assessed by the oral glucose tolerance test in 21 non-diabetic ALS patients and compared with 21 age- and sex-matched normal subjects. Lipids and lactate/pyruvate ratio, levels of pro-inflammatory cytokines (tumour necrosis factor-alpha and interleukin-6) and adipocytokines (leptin and adiponectin) were also measured in ALS patients. Mann-Whitney U-tests analysed continuous data and Fisher's exact tests assessed categorical data. Blood glucose determined 120 min after the glucose bolus was significantly higher in patients with ALS (7.41 mmol/l+/-1.68) compared to controls (6.05+/-1.44, p=0.006). ALS patients with impaired glucose tolerance (IGT) according to WHO criteria (n=7, 33%) were more likely to have elevated free fatty acids (FFA) levels compared to patients with normal glucose tolerance (0.77 nmol/l+/-0.30 vs. 0.57+/-0.19, p=0.04). IGT was not associated with disease duration or severity. In conclusion, patients with ALS show abnormal glucose tolerance that could be associated with increased FFA levels, a key determinant of insulin resistance. The origin of glucose homeostasis abnormalities in ALS may be multifactorial and deserves further investigation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adiponectin,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Nonesterified,
http://linkedlifedata.com/resource/pubmed/chemical/IL6 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Lactic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Leptin,
http://linkedlifedata.com/resource/pubmed/chemical/Pyruvic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/adiponectin, human
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-180X
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pubmed:author |
pubmed-author:Bonnefont-RousselotDominiqueD,
pubmed-author:BruneteauGaelleG,
pubmed-author:CorciaPhilippeP,
pubmed-author:CoussieuChristianeC,
pubmed-author:DupuisLucL,
pubmed-author:FrochotVincentV,
pubmed-author:GordonPaul HPH,
pubmed-author:JardelClaudeC,
pubmed-author:LacomblezLucetteL,
pubmed-author:LacorteJean-MarcJM,
pubmed-author:Le ForestierNadineN,
pubmed-author:LoefflerJean-PhilippeJP,
pubmed-author:MeiningerVincentV,
pubmed-author:PradatPierre-FrancoisPF,
pubmed-author:SalachasFrancoisF,
pubmed-author:SimonDominiqueD
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
166-71
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20184518-Adiponectin,
pubmed-meshheading:20184518-Adolescent,
pubmed-meshheading:20184518-Adult,
pubmed-meshheading:20184518-Aged,
pubmed-meshheading:20184518-Amyotrophic Lateral Sclerosis,
pubmed-meshheading:20184518-Blood Glucose,
pubmed-meshheading:20184518-Fatty Acids, Nonesterified,
pubmed-meshheading:20184518-Female,
pubmed-meshheading:20184518-Glucose Intolerance,
pubmed-meshheading:20184518-Glucose Tolerance Test,
pubmed-meshheading:20184518-Humans,
pubmed-meshheading:20184518-Insulin,
pubmed-meshheading:20184518-Interleukin-6,
pubmed-meshheading:20184518-Lactic Acid,
pubmed-meshheading:20184518-Leptin,
pubmed-meshheading:20184518-Male,
pubmed-meshheading:20184518-Middle Aged,
pubmed-meshheading:20184518-Pyruvic Acid,
pubmed-meshheading:20184518-Tumor Necrosis Factor-alpha,
pubmed-meshheading:20184518-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Impaired glucose tolerance in patients with amyotrophic lateral sclerosis.
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pubmed:affiliation |
APHP, Hôpital de la Pitié-Salpêtrière, Fédération des Maladies du Système Nerveux, Paris, France. pierre-francois.pradat@psl.aphp.fr <pierre-francois.pradat@psl.aphp.fr>
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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