Linked Life Data

20184462

Source:http://linkedlifedata.com/resource/pubmed/id/20184462

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-2-26
pubmed:abstractText
With histochemical methods an instantaneous and marked inhibitory effect of a single dose of colchicine on the activity of succinic-, lactic-, glucose-6-phosphate-, NADH- and NADPH-dehydrogenase in the mouse liver was observed. This effect was essentially the same as that previously described in the intestinal mucosa and not dependent on or a consequence of the inhibitory effect of colchicine on cell division. The enzymatic inhibitory effect of colchicine was qualitatively similar regardless of the dose of the drug given, although a single large dose (1.5 mg/kg body weight) produced alterations and depression of dehydrogenase activity more marked and not so rapidly repaired as those appearing after a small dose of colchicine (0.24 mg/kg body weight). Following repeated doses of colchicine the degree of histochemically demonstrable depression of dehydrogenase activity was not obviously different from that found after a single dose. After large repeated doses morphological alterations and prolonged depression of dehydrogenase activity of liver cells were found and many of the animals died. After repeated administration of the small dose (0.24 mg/kg body weight) no morphological alterations were found and the activity of dehydrogenases was normalized, although the injection of colchicine was continued.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1502-7708
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7-17
pubmed:meshHeading
pubmed:year
1967
pubmed:articleTitle
Colchicine effects on the mouse liver.
pubmed:affiliation
Division of Gastroenterology, Department of Medicine and Pathology, University of Alabama Medical Center, Birmingham, Alabama, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural