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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-3-16
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pubmed:abstractText |
Atopic and non-atopic wheezing may be caused by different etiologies: while eosinophils are more important in atopic asthmatic wheezers, neutrophils are predominantly found in BAL samples of young children with wheezing. Both neutrophils as well as eosinophils may secrete matrix metalloproteinase 9 (MMP-9). Considering that MMP-9 plays an important role in airway wall thickening and airway inflammation, it may influence the development of obstructive airway phenotypes in children. In the present study we investigated whether genetic variations in MMP-9 influence the development of different forms of childhood asthma.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1465-993X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
23
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pubmed:dateRevised |
2010-9-30
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pubmed:meshHeading |
pubmed-meshheading:20181264-Asthma,
pubmed-meshheading:20181264-Child,
pubmed-meshheading:20181264-Female,
pubmed-meshheading:20181264-Genetic Predisposition to Disease,
pubmed-meshheading:20181264-Genetic Variation,
pubmed-meshheading:20181264-Germany,
pubmed-meshheading:20181264-Humans,
pubmed-meshheading:20181264-Hypersensitivity, Immediate,
pubmed-meshheading:20181264-Incidence,
pubmed-meshheading:20181264-Male,
pubmed-meshheading:20181264-Matrix Metalloproteinase 9,
pubmed-meshheading:20181264-Mutation,
pubmed-meshheading:20181264-Polymorphism, Single Nucleotide,
pubmed-meshheading:20181264-Risk Assessment,
pubmed-meshheading:20181264-Risk Factors
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pubmed:year |
2010
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pubmed:articleTitle |
MMP-9 gene variants increase the risk for non-atopic asthma in children.
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pubmed:affiliation |
Department of Pediatric Pneumology and Neonatology, Hannover Medical School, Hannover, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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