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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4 Pt 1
|
| pubmed:dateCreated |
1991-5-17
|
| pubmed:abstractText |
The role of glucose transporters GLUT-1 and GLUT-4 in the development of insulin sensitivity at weaning in rat skeletal muscles and adipose tissue was studied in relation to the nutritional changes when suckling rats shift from a high-fat (HF) to a high-carbohydrate (HCHO) diet. Insulin stimulated the translocation of GLUT-4 protein from an intracellular pool to the plasma membrane in adipocytes from suckling and HCHO- or HF-weaned rats. The GLUT-4 protein and the insulin stimulation were threefold higher in adipocytes from HCHO-weaned rats than in suckling or HF-weaned rats. GLUT-4 mRNA and protein were low in adipose tissue and skeletal muscles of suckling rats and increased two- to threefold in HCHO-weaned rats. This increase was prevented in HF-weaned rats. GLUT-1 mRNA was not affected in both tissues by the developmental stage or the nutritional environment. After feeding HCHO to a suckling rat, GLUT-4 mRNA was threefold increased in 6 days and reached a peak after 4 days in both tissues. The insulin sensitivity of glucose transport in rats at weaning might be conferred by an enhanced expression of GLUT-4, which can be induced within a few hours after feeding a HCHO diet.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA Probes,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Carbohydrates,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Monosaccharide Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0002-9513
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
260
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
E588-93
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2018122-Adipose Tissue,
pubmed-meshheading:2018122-Aging,
pubmed-meshheading:2018122-Animals,
pubmed-meshheading:2018122-Animals, Suckling,
pubmed-meshheading:2018122-Blotting, Northern,
pubmed-meshheading:2018122-Cell Membrane,
pubmed-meshheading:2018122-Cells, Cultured,
pubmed-meshheading:2018122-DNA Probes,
pubmed-meshheading:2018122-Diet,
pubmed-meshheading:2018122-Dietary Carbohydrates,
pubmed-meshheading:2018122-Dietary Fats,
pubmed-meshheading:2018122-Homeostasis,
pubmed-meshheading:2018122-Insulin,
pubmed-meshheading:2018122-Microsomes,
pubmed-meshheading:2018122-Monosaccharide Transport Proteins,
pubmed-meshheading:2018122-Muscle Development,
pubmed-meshheading:2018122-Muscles,
pubmed-meshheading:2018122-Protein Processing, Post-Translational,
pubmed-meshheading:2018122-RNA, Messenger,
pubmed-meshheading:2018122-Rats,
pubmed-meshheading:2018122-Rats, Inbred Strains,
pubmed-meshheading:2018122-Weaning
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Nutritional regulation of glucose transporter in muscle and adipose tissue of weaned rats.
|
| pubmed:affiliation |
Centre de Recherche sur la Nutrition, Centre National de la Recherche Scientifique, Meudon-Bellevue, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|