|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2010-6-22
|
|
pubmed:abstractText |
Activated protein C (APC) in complex with endothelial protein C receptor (EPCR) can reverse the barrier-disruptive and cytotoxic effects of proinflammatory cytokines by cleaving protease-activated receptor 1 (PAR-1). Recently, it was reported that the PAR-1-dependent vascular barrier-protective effect of APC is mediated through transactivation of the angiopoietin (Ang)-Tie2 signaling pathway. The antagonist of this pathway, Ang2, is stored in Weibel-Palade bodies within endothelial cells.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20180904-11009566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20180904-11283723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20180904-12052963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20180904-15166095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20180904-15172966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20180904-15626732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20180904-15665002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20180904-15710622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20180904-16102047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20180904-17045842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20180904-1710835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20180904-17110453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20180904-17299037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20180904-17823308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20180904-18612544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20180904-19189342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20180904-19615361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20180904-7688665
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
1538-7836
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
8
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1107-15
|
|
pubmed:dateRevised |
2011-7-28
|
|
pubmed:meshHeading |
pubmed-meshheading:20180904-Angiopoietin-2,
pubmed-meshheading:20180904-Cell Line, Transformed,
pubmed-meshheading:20180904-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:20180904-Humans,
pubmed-meshheading:20180904-P-Selectin,
pubmed-meshheading:20180904-Phosphorylation,
pubmed-meshheading:20180904-Receptor, TIE-2,
pubmed-meshheading:20180904-Thrombin,
pubmed-meshheading:20180904-Up-Regulation,
pubmed-meshheading:20180904-Weibel-Palade Bodies
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Thrombin upregulates the angiopoietin-Tie2 Axis: endothelial protein C receptor occupancy prevents the thrombin mobilization of angiopoietin 2 and P-selectin from Weibel-Palade bodies.
|
|
pubmed:affiliation |
Department of Herbal Pharmaceutical Engineering, College of Herbal Bio-Industry, Daegu Haany University, Gyeongsan, Korea. BaeJS@dhu.ac.kr
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
