Linked Life Data

20180053

Source:http://linkedlifedata.com/resource/pubmed/id/20180053

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pubmed-article:20180053pubmed:abstractTextThe purpose of the present work was the development and evaluation of stomach-specific controlled release mucoadhesive drug delivery system prepared by ionotropic gelation of gellan beads, containing acid-soluble drug amoxicillin trihydrate, using 3(2) factorial design with concentration of gellan gum and quantity of drug as variables. The study showed that beads prepared in alkaline cross-linking medium have higher entrapment efficiency than the acidic cross-linking medium. The entrapment efficiency was in the range of 32% to 46% w/w in acidic medium, which increased up to 60% to 90% w/w in alkaline medium. Batches with lowest, medium, and highest drug entrapment were subjected to chitosan coating to form a polyelectrolyte complex film. As polymer concentration increases, entrapment efficiency and particle size increases. Scanning electron microscopy revealed spherical but rough surface due to leaching of drug in acidic cross-linking solution, dense spherical structure in alkaline cross-linking solution, and rough surface of chitosan-coated beads with minor wrinkles. The in vitro drug release up to 7 h in a controlled manner following the Peppas model (r = 0.9998). In vitro and in vivo mucoadhesivity study showed that beads have good mucoadhesivity and more than 85% beads remained adhered to stomach mucosa of albino rat even after 7 h. In vitro growth inhibition study showed complete eradication of Helicobacter pylori. These results indicate that stomach-specific controlled release mucoadhesive system of amoxicillin gellan beads may be useful in H. pylori treatment.lld:pubmed
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pubmed-article:20180053pubmed:dateRevised2011-2-25lld:pubmed
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pubmed-article:20180053pubmed:articleTitleStomach-specific controlled release gellan beads of acid-soluble drug prepared by ionotropic gelation method.lld:pubmed
pubmed-article:20180053pubmed:affiliationDepartment of Pharmaceutics, Poona College of Pharmacy, Bharti Vidyapeeth University, Erandwane, Pune, 411038 Maharashtra, India.lld:pubmed
pubmed-article:20180053pubmed:publicationTypeJournal Articlelld:pubmed