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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2010-7-2
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pubmed:abstractText |
Residual chronic myeloid leukemia disease following imatinib treatment has been attributed to the presence of quiescent leukemic stem cells intrinsically resistant to imatinib. Mesenchymal stromal cells in the bone marrow may favor the persistence and progression of leukemia by preserving the proliferation and self-renewal capacities of the malignant progenitor cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20179085-10519415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20179085-10728684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20179085-10803521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20179085-11237532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20179085-11322829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20179085-11756187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20179085-12531874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20179085-14764882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20179085-15260986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20179085-15549095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20179085-15591115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20179085-15805265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20179085-15815728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20179085-15882617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20179085-16175394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20179085-16469872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20179085-16707466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20179085-17151364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20179085-17170725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20179085-17213283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20179085-17220794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20179085-17380207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20179085-18202009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20179085-19139079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20179085-19262595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20179085-2163544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20179085-3528680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20179085-9516138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20179085-9734397
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1592-8721
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pubmed:author |
pubmed-author:ApperleyJaneJ,
pubmed-author:BonnetDominiqueD,
pubmed-author:DazziFrancescoF,
pubmed-author:GomesAna RAR,
pubmed-author:HoKa-KeiKK,
pubmed-author:LamEric W-FEW,
pubmed-author:LymperiStefaniaS,
pubmed-author:MarinDavidD,
pubmed-author:TisatoVeronicaV,
pubmed-author:VianelloFabrizioF,
pubmed-author:VillanovaFedericaF
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pubmed:issnType |
Electronic
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pubmed:volume |
95
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1081-9
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pubmed:dateRevised |
2010-9-30
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pubmed:meshHeading |
pubmed-meshheading:20179085-Animals,
pubmed-meshheading:20179085-Apoptosis,
pubmed-meshheading:20179085-Bone Marrow Cells,
pubmed-meshheading:20179085-Chemokine CXCL12,
pubmed-meshheading:20179085-Coculture Techniques,
pubmed-meshheading:20179085-Drug Resistance, Neoplasm,
pubmed-meshheading:20179085-Humans,
pubmed-meshheading:20179085-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:20179085-Mesenchymal Stem Cells,
pubmed-meshheading:20179085-Mice,
pubmed-meshheading:20179085-Mice, SCID,
pubmed-meshheading:20179085-Piperazines,
pubmed-meshheading:20179085-Pyrimidines,
pubmed-meshheading:20179085-Receptors, CXCR4,
pubmed-meshheading:20179085-Stromal Cells,
pubmed-meshheading:20179085-Tumor Cells, Cultured
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pubmed:year |
2010
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pubmed:articleTitle |
Bone marrow mesenchymal stromal cells non-selectively protect chronic myeloid leukemia cells from imatinib-induced apoptosis via the CXCR4/CXCL12 axis.
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pubmed:affiliation |
Department of Haematology, Kennedy Institute of Rheumatology, Imperial College, London, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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