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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1991-5-17
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pubmed:abstractText |
Sodium N-benzyl-D-glucamine dithiocarbamate (BGD) was evaluated for its efficacy as an inhibitor of cis-diamminedichloroplatinum (DDP)-induced nephrotoxicity in a rat model. Treatment with 2.0 mmol/kg of BGD immediately after DDP injection effectively prevented nephrotoxic effects of DDP, but administration of BGD -1 or 1 h after DDP afforded a small protection. Concurrent treatment with 0.5 mmol/kg of BGD could not prevent renal damage. The platinum concentrations in liver and kidney were significantly decreased by BGD treatment. The antitumor efficacy of DDP in the Walker 256 carcinoma-bearing rats was not affected by administration of BGD (2.0 mmol/kg).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0300-483X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
41-51
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:2017764-Animals,
pubmed-meshheading:2017764-Aspartate Aminotransferases,
pubmed-meshheading:2017764-Blood Urea Nitrogen,
pubmed-meshheading:2017764-Body Weight,
pubmed-meshheading:2017764-Carcinoma 256, Walker,
pubmed-meshheading:2017764-Cisplatin,
pubmed-meshheading:2017764-Female,
pubmed-meshheading:2017764-Glycosuria,
pubmed-meshheading:2017764-Kidney,
pubmed-meshheading:2017764-Liver,
pubmed-meshheading:2017764-Male,
pubmed-meshheading:2017764-Platinum,
pubmed-meshheading:2017764-Proteinuria,
pubmed-meshheading:2017764-Random Allocation,
pubmed-meshheading:2017764-Rats,
pubmed-meshheading:2017764-Rats, Inbred Strains,
pubmed-meshheading:2017764-Sorbitol,
pubmed-meshheading:2017764-Thiocarbamates
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pubmed:year |
1991
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pubmed:articleTitle |
Protection against cis-diamminedichloroplatinum-induced nephrotoxicity in rats by N-benzyl-D-glucamine dithiocarbamate.
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pubmed:affiliation |
Department of School Health, Faculty of Education, Kumamoto University, Japan.
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pubmed:publicationType |
Journal Article
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