| pubmed-article:20176955 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20176955 | lifeskim:mentions | umls-concept:C0002708 | lld:lifeskim |
| pubmed-article:20176955 | lifeskim:mentions | umls-concept:C0080093 | lld:lifeskim |
| pubmed-article:20176955 | lifeskim:mentions | umls-concept:C0678558 | lld:lifeskim |
| pubmed-article:20176955 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:20176955 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:20176955 | pubmed:dateCreated | 2010-3-10 | lld:pubmed |
| pubmed-article:20176955 | pubmed:abstractText | Despite considerable evidence for a critical role of neuroligin-1 in the specification of excitatory synapses, the cellular mechanisms and physiological roles of neuroligin-1 in mature neural circuits are poorly understood. In mutant mice deficient in neuroligin-1, or adult rats in which neuroligin-1 was depleted, we have found that neuroligin-1 stabilizes the NMDA receptors residing in the postsynaptic membrane of amygdala principal neurons, which allows for a normal range of NMDA receptor-mediated synaptic transmission. We observed marked decreases in NMDA receptor-mediated synaptic currents at afferent inputs to the amygdala of neuroligin-1 knockout mice. However, the knockout mice exhibited a significant impairment in spike-timing-dependent long-term potentiation (STD-LTP) at the thalamic but not the cortical inputs to the amygdala. Subsequent electrophysiological analyses indicated that STD-LTP in the cortical pathway is largely independent of activation of postsynaptic NMDA receptors. These findings suggest that neuroligin-1 can modulate, in a pathway-specific manner, synaptic plasticity in the amygdala circuits of adult animals, likely by regulating the abundance of postsynaptic NMDA receptors. | lld:pubmed |
| pubmed-article:20176955 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20176955 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20176955 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20176955 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20176955 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20176955 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20176955 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20176955 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20176955 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20176955 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20176955 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:20176955 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:20176955 | pubmed:author | pubmed-author:KandelEric... | lld:pubmed |
| pubmed-article:20176955 | pubmed:author | pubmed-author:LeeC JustinCJ | lld:pubmed |
| pubmed-article:20176955 | pubmed:author | pubmed-author:KimJoung-HunJ... | lld:pubmed |
| pubmed-article:20176955 | pubmed:author | pubmed-author:ChoiYun-BeomY... | lld:pubmed |
| pubmed-article:20176955 | pubmed:author | pubmed-author:BaileyCraig... | lld:pubmed |
| pubmed-article:20176955 | pubmed:author | pubmed-author:KimJuhyunJ | lld:pubmed |
| pubmed-article:20176955 | pubmed:author | pubmed-author:JungSang-Yong... | lld:pubmed |
| pubmed-article:20176955 | pubmed:author | pubmed-author:KwonOh BinOB | lld:pubmed |
| pubmed-article:20176955 | pubmed:author | pubmed-author:JeongA... | lld:pubmed |
| pubmed-article:20176955 | pubmed:author | pubmed-author:JungJung... | lld:pubmed |
| pubmed-article:20176955 | pubmed:author | pubmed-author:AnKyongmanK | lld:pubmed |
| pubmed-article:20176955 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20176955 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:20176955 | pubmed:volume | 107 | lld:pubmed |
| pubmed-article:20176955 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20176955 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20176955 | pubmed:pagination | 4710-5 | lld:pubmed |
| pubmed-article:20176955 | pubmed:dateRevised | 2010-9-10 | lld:pubmed |
| pubmed-article:20176955 | pubmed:meshHeading | pubmed-meshheading:20176955... | lld:pubmed |
| pubmed-article:20176955 | pubmed:meshHeading | pubmed-meshheading:20176955... | lld:pubmed |
| pubmed-article:20176955 | pubmed:meshHeading | pubmed-meshheading:20176955... | lld:pubmed |
| pubmed-article:20176955 | pubmed:meshHeading | pubmed-meshheading:20176955... | lld:pubmed |
| pubmed-article:20176955 | pubmed:meshHeading | pubmed-meshheading:20176955... | lld:pubmed |
| pubmed-article:20176955 | pubmed:meshHeading | pubmed-meshheading:20176955... | lld:pubmed |
| pubmed-article:20176955 | pubmed:meshHeading | pubmed-meshheading:20176955... | lld:pubmed |
| pubmed-article:20176955 | pubmed:meshHeading | pubmed-meshheading:20176955... | lld:pubmed |
| pubmed-article:20176955 | pubmed:meshHeading | pubmed-meshheading:20176955... | lld:pubmed |
| pubmed-article:20176955 | pubmed:meshHeading | pubmed-meshheading:20176955... | lld:pubmed |
| pubmed-article:20176955 | pubmed:meshHeading | pubmed-meshheading:20176955... | lld:pubmed |
| pubmed-article:20176955 | pubmed:meshHeading | pubmed-meshheading:20176955... | lld:pubmed |
| pubmed-article:20176955 | pubmed:meshHeading | pubmed-meshheading:20176955... | lld:pubmed |
| pubmed-article:20176955 | pubmed:meshHeading | pubmed-meshheading:20176955... | lld:pubmed |
| pubmed-article:20176955 | pubmed:meshHeading | pubmed-meshheading:20176955... | lld:pubmed |
| pubmed-article:20176955 | pubmed:meshHeading | pubmed-meshheading:20176955... | lld:pubmed |
| pubmed-article:20176955 | pubmed:meshHeading | pubmed-meshheading:20176955... | lld:pubmed |
| pubmed-article:20176955 | pubmed:meshHeading | pubmed-meshheading:20176955... | lld:pubmed |
| pubmed-article:20176955 | pubmed:meshHeading | pubmed-meshheading:20176955... | lld:pubmed |
| pubmed-article:20176955 | pubmed:meshHeading | pubmed-meshheading:20176955... | lld:pubmed |
| pubmed-article:20176955 | pubmed:meshHeading | pubmed-meshheading:20176955... | lld:pubmed |
| pubmed-article:20176955 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20176955 | pubmed:articleTitle | Input-specific synaptic plasticity in the amygdala is regulated by neuroligin-1 via postsynaptic NMDA receptors. | lld:pubmed |
| pubmed-article:20176955 | pubmed:affiliation | Department of Life Science, Pohang University of Science and Technology, Pohang, Gyungbuk 790-784, Korea. | lld:pubmed |
| pubmed-article:20176955 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20176955 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:192167 | entrezgene:pubmed | pubmed-article:20176955 | lld:entrezgene |
| entrez-gene:116647 | entrezgene:pubmed | pubmed-article:20176955 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20176955 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20176955 | lld:entrezgene |
