|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2010-6-10
|
|
pubmed:abstractText |
Patients with chronic hepatitis C virus (HCV) infections are treated with pegylated interferon and ribavirin (PEG-IFN/RBV), which is effective in less than 50% of those infected with HCV genotype 1. Genome-wide association studies have linked response to PEG-IFN/RBV with common single nucleotide polymorphisms in the vicinity of interferon (IFN)-lambda genes on chromosome 19. We investigated the association between the polymorphism rs12979860 and treatment response in a diverse cohort of chronic HCV patients.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20176026-10084106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20176026-10451460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20176026-11583749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20176026-12324553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20176026-14996676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20176026-15731279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20176026-16146571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20176026-16702586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20176026-17087946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20176026-17569110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20176026-17625010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20176026-19749757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20176026-19749758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20176026-8049640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20176026-8122051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20176026-8389799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20176026-9160492
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antiviral Agents,
http://linkedlifedata.com/resource/pubmed/chemical/IL28B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukins,
http://linkedlifedata.com/resource/pubmed/chemical/Polyethylene Glycols,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ribavirin,
http://linkedlifedata.com/resource/pubmed/chemical/interferon alfa-2a,
http://linkedlifedata.com/resource/pubmed/chemical/interferon alfa-2b,
http://linkedlifedata.com/resource/pubmed/chemical/peginterferon alfa-2a,
http://linkedlifedata.com/resource/pubmed/chemical/peginterferon alfa-2b
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
1528-0012
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
138
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2307-14
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:20176026-Adult,
pubmed-meshheading:20176026-Antiviral Agents,
pubmed-meshheading:20176026-Drug Therapy, Combination,
pubmed-meshheading:20176026-Female,
pubmed-meshheading:20176026-Genotype,
pubmed-meshheading:20176026-Hepacivirus,
pubmed-meshheading:20176026-Hepatitis C, Chronic,
pubmed-meshheading:20176026-Humans,
pubmed-meshheading:20176026-Interferon-alpha,
pubmed-meshheading:20176026-Interleukins,
pubmed-meshheading:20176026-Male,
pubmed-meshheading:20176026-Middle Aged,
pubmed-meshheading:20176026-Polyethylene Glycols,
pubmed-meshheading:20176026-Recombinant Proteins,
pubmed-meshheading:20176026-Ribavirin,
pubmed-meshheading:20176026-Viral Load
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Replicated association between an IL28B gene variant and a sustained response to pegylated interferon and ribavirin.
|
|
pubmed:affiliation |
Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina 27708, USA. jeanette.mccarthy@duke.edu
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
