Source:http://linkedlifedata.com/resource/pubmed/id/20174761
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2010-4-1
|
| pubmed:abstractText |
Bactericidal/permeability-increasing protein (BPI), a major constituent of neutrophils that possesses anti-inflammatory properties, shows a structure similar to some proteins implicated in lipid metabolism. We evaluated circulating BPI as a biomarker of endothelial function and lipid metabolism. Circulating BPI concentrations (ELISA) and serum lipids were measured in 202 Caucasian non-smoking men. In a subgroup of 91 consecutive subjects brachial vascular reactivity (high resolution external ultrasound) was assessed. Plasma BPI concentrations were positively associated with total cholesterol (TC), LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C) (r= 0.203, 0.204 and 0.18; all p<0.05, respectively). In a multiple linear regression analysis, BPI levels were independent contributors to the variance of HDL-C, total cholesterol and LDL-cholesterol after adjusting for age, body mass index and glucose tolerance status. Plasma BPI concentration correlated positively with endothelium-dependent vasodilatation (r=0.277; p<0.05) and HDL-C (r=0.36; p<0.05) in subjects with normal glucose tolerance. In conclusion, circulating BPI could constitute a biomarker of lipid metabolism in subjects with normal glucose tolerance and could help to identify those subjects with preserved endothelial function.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antimicrobial Cationic Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/bactericidal permeability...
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0340-6245
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
103
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
780-7
|
| pubmed:dateRevised |
2010-10-7
|
| pubmed:meshHeading |
pubmed-meshheading:20174761-Adult,
pubmed-meshheading:20174761-Aged,
pubmed-meshheading:20174761-Antimicrobial Cationic Peptides,
pubmed-meshheading:20174761-Biological Markers,
pubmed-meshheading:20174761-Blood Glucose,
pubmed-meshheading:20174761-Blood Proteins,
pubmed-meshheading:20174761-Brachial Artery,
pubmed-meshheading:20174761-Endothelium, Vascular,
pubmed-meshheading:20174761-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:20174761-European Continental Ancestry Group,
pubmed-meshheading:20174761-Glucose Tolerance Test,
pubmed-meshheading:20174761-Humans,
pubmed-meshheading:20174761-Linear Models,
pubmed-meshheading:20174761-Lipids,
pubmed-meshheading:20174761-Male,
pubmed-meshheading:20174761-Middle Aged,
pubmed-meshheading:20174761-Spain,
pubmed-meshheading:20174761-Vasodilation
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Circulating bactericidal/permeability-increasing protein (BPI) is associated with serum lipids and endothelial function.
|
| pubmed:affiliation |
Section of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomédica de Girona, Girona, Spain.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|