rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1
|
pubmed:dateCreated |
2010-2-22
|
pubmed:abstractText |
Bosentan is an endothelin-receptor antagonist that reportedly induces both cytochrome P450 (CYP) 3A4 and CYP2C9 enzymes, which are also involved in warfarin metabolism. We present a case report describing a probable drug interaction between warfarin and bosentan in a patient with pulmonary hypertension.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anticoagulants,
http://linkedlifedata.com/resource/pubmed/chemical/Antihypertensive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Aryl Hydrocarbon Hydroxylases,
http://linkedlifedata.com/resource/pubmed/chemical/CYP2C9 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CYP3A4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP3A,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/Warfarin,
http://linkedlifedata.com/resource/pubmed/chemical/bosentan
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
1879-114X
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:volume |
32
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
53-6
|
pubmed:meshHeading |
pubmed-meshheading:20171411-Anticoagulants,
pubmed-meshheading:20171411-Antihypertensive Agents,
pubmed-meshheading:20171411-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:20171411-Cytochrome P-450 CYP3A,
pubmed-meshheading:20171411-Dose-Response Relationship, Drug,
pubmed-meshheading:20171411-Drug Administration Schedule,
pubmed-meshheading:20171411-Drug Interactions,
pubmed-meshheading:20171411-Female,
pubmed-meshheading:20171411-Humans,
pubmed-meshheading:20171411-Hypertension, Pulmonary,
pubmed-meshheading:20171411-International Normalized Ratio,
pubmed-meshheading:20171411-Middle Aged,
pubmed-meshheading:20171411-Pulmonary Embolism,
pubmed-meshheading:20171411-Sulfonamides,
pubmed-meshheading:20171411-Treatment Outcome,
pubmed-meshheading:20171411-Warfarin
|
pubmed:year |
2010
|
pubmed:articleTitle |
Warfarin and bosentan interaction in a patient with pulmonary hypertension secondary to bilateral pulmonary emboli.
|
pubmed:affiliation |
Creighton University School of Pharmacy and Health Professions, Omaha, Nebraska 68178, USA. mikaylaspangler@creighton.edu
|
pubmed:publicationType |
Journal Article,
Case Reports
|