Linked Life Data

20170291

Source:http://linkedlifedata.com/resource/pubmed/id/20170291

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-3-19
pubmed:abstractText
Abstract Background. High levels of high-sensitivity C-reactive protein (hs-CRP) are associated with depressed mood, but the causal relationships are not known. Therefore, we examined the relationships between hs-CRP and incident depressed mood among the elderly. Methods. Altogether 764 (69%) individuals out of a representative sample of subjects aged 70 years or older (N = 1113) were screened with the Short Zung Self Rating Depression Scale (SZSRDS), and serum hs-CRP determinations were done at the same time. After a two-and-a-half-year follow-up, the SZSRDS examinations were repeated among those who were free of depressed mood (SZSRDS score >or=28 or use of an anti-depressant drug) at the baseline (N = 404). Analysis of covariance (ANCOVA) and logistic regression were used to analyse the relationship between the baseline hs-CRP (<1, 1 < 3, 3 <10 mg/L) and the follow-up SZSRDS scores (10-40) and depressed mood. Results. Baseline hs-CRP was not associated with an increasing trend in SZSRDS scores and depressed mood in the total study population, but there was a significant gender interaction. Among the men, elevated hs-CRP was associated with an increasing trend in the SZSRDS score and depressed mood. Conclusions. High hs-CRP predicts a higher incident SZSRDS score and depressed mood among older men, suggesting a possible inflammatory etiology for depression.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1502-7686
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
75-9
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
The relationships between high-sensitivity C-reactive protein and incident depressed mood among older adults.
pubmed:affiliation
Department of Medical Rehabilitation, Oulu University Hospital, Institute of Health Sciences, University of Oulu, Oulu, Finland. heikki.luukinen@oulu.fi
pubmed:publicationType
Journal Article