rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
10
|
pubmed:dateCreated |
2010-3-10
|
pubmed:abstractText |
The identification, synthesis, and evaluation of a series of naphthoquinone derivatives as selective inhibitors of human arylamine N-acetyltransferase 1 and mouse arylamine N-acetyltransferase 2 are described. The compounds undergo a distinctive color change (red --> blue) upon binding to these human and mouse NAT isoenzymes driven by a proton transfer event. No color change is observed in the presence of functionally distinct but highly similar isoenzymes which are >70% identical. These molecules may be used as sensors to detect the presence of human NAT1 in cell lysates.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
1520-5126
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:day |
17
|
pubmed:volume |
132
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
3238-9
|
pubmed:meshHeading |
pubmed-meshheading:20170182-Animals,
pubmed-meshheading:20170182-Arylamine N-Acetyltransferase,
pubmed-meshheading:20170182-Breast Neoplasms,
pubmed-meshheading:20170182-Colorimetry,
pubmed-meshheading:20170182-Female,
pubmed-meshheading:20170182-Humans,
pubmed-meshheading:20170182-Isoenzymes,
pubmed-meshheading:20170182-Mice,
pubmed-meshheading:20170182-Models, Molecular,
pubmed-meshheading:20170182-Tumor Markers, Biological
|
pubmed:year |
2010
|
pubmed:articleTitle |
Small molecule colorimetric probes for specific detection of human arylamine N-acetyltransferase 1, a potential breast cancer biomarker.
|
pubmed:affiliation |
Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|