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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-3-18
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pubmed:abstractText |
Novel 5-cyclic amine-3-arylsulfonylindazoles were prepared, and several analogues within this class have been identified as high-affinity 5-HT(6) receptor ligands with improved pharmacokinetic and pharmacological properties. One selected example, 18b, showed good brain penetrability and a generally favorable pharmacokinetic profile with procognitive efficacy in the rat novel object recognition assay. The synthesis and structure-activity relationship of this potent class are discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1520-4804
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pubmed:author |
pubmed-author:AndraePatrick MPM,
pubmed-author:AschmiesSuzanS,
pubmed-author:ComeryThomas ATA,
pubmed-author:GrafRadkaR,
pubmed-author:HaydarSimon NSN,
pubmed-author:HuseltonChristineC,
pubmed-author:KramerAngelaA,
pubmed-author:MattesJamesJ,
pubmed-author:RobichaudAlbert JAJ,
pubmed-author:SchechterLee ELE,
pubmed-author:SmithDeborah LDL,
pubmed-author:YunHeedongH,
pubmed-author:ZhangJeanJ
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pubmed:issnType |
Electronic
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pubmed:day |
25
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2521-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:20170099-Animals,
pubmed-meshheading:20170099-Binding, Competitive,
pubmed-meshheading:20170099-Brain,
pubmed-meshheading:20170099-Exploratory Behavior,
pubmed-meshheading:20170099-Habituation, Psychophysiologic,
pubmed-meshheading:20170099-Humans,
pubmed-meshheading:20170099-Indazoles,
pubmed-meshheading:20170099-Models, Chemical,
pubmed-meshheading:20170099-Molecular Structure,
pubmed-meshheading:20170099-Rats,
pubmed-meshheading:20170099-Receptor, Serotonin, 5-HT2B,
pubmed-meshheading:20170099-Receptors, Serotonin,
pubmed-meshheading:20170099-Recognition (Psychology),
pubmed-meshheading:20170099-Serotonin 5-HT2 Receptor Antagonists,
pubmed-meshheading:20170099-Serotonin Antagonists,
pubmed-meshheading:20170099-Structure-Activity Relationship,
pubmed-meshheading:20170099-Sulfones
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pubmed:year |
2010
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pubmed:articleTitle |
5-Cyclic amine-3-arylsulfonylindazoles as novel 5-HT6 receptor antagonists.
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pubmed:affiliation |
Wyeth Research, CN 8000, Princeton, New Jersey 08543, USA. Haydars@wyeth.com
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pubmed:publicationType |
Journal Article
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