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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-4-15
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pubmed:abstractText |
We previously reported increased binding of (+)[11C]DTBZ (dihydrotetrabenazine), the vesicular monoamine transporter (VMAT2) positron emission tomography (PET) radioligand, in striatum of some methamphetamine users. This finding might be explained by stimulant-induced vesicular DA depletion resulting in decreased DA (+)[11C]DTBZ competition at VMAT2. In a prospective PET study, we now find that administration of an acute oral dose of amphetamine (0.4 mg/kg) to humans does not cause increased striatal (+)[11C]DTBZ binding but a slight 5% decrease. Our data suggest that a low amphetamine dose is unlikely to cause sufficient DA depletion to detect increased (+)[11C]DTBZ binding and that a higher dose might be required.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1098-2396
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
417-20
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pubmed:meshHeading |
pubmed-meshheading:20169578-Administration, Oral,
pubmed-meshheading:20169578-Adult,
pubmed-meshheading:20169578-Amphetamine,
pubmed-meshheading:20169578-Amphetamine-Related Disorders,
pubmed-meshheading:20169578-Binding, Competitive,
pubmed-meshheading:20169578-Central Nervous System Stimulants,
pubmed-meshheading:20169578-Corpus Striatum,
pubmed-meshheading:20169578-Dopamine,
pubmed-meshheading:20169578-Dose-Response Relationship, Drug,
pubmed-meshheading:20169578-Female,
pubmed-meshheading:20169578-Humans,
pubmed-meshheading:20169578-Male,
pubmed-meshheading:20169578-Positron-Emission Tomography,
pubmed-meshheading:20169578-Prospective Studies,
pubmed-meshheading:20169578-Tetrabenazine,
pubmed-meshheading:20169578-Vesicular Monoamine Transport Proteins,
pubmed-meshheading:20169578-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Influence of a low dose of amphetamine on vesicular monoamine transporter binding: a PET (+)[11C]DTBZ study in humans.
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pubmed:affiliation |
Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada. isabelle_boileau@camh.net
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pubmed:publicationType |
Journal Article
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