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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-2-19
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pubmed:abstractText |
We have previously shown a different local and systemic angiogenic profile of CXC chemokines in Idiopathic Pulmonary Fibrosis (IPF) patients compared to sarcoidosis. In particular, sarcoidosis showed an angiostatic microenvironment, as compared with the angiogenic cytokine milieu seen in IPF. Purpose of the Study. Our aim was to further investigate the aforementioned finding by measuring the expression of different chemokines in granulomatous and fibrotic diseases. We estimated the levels of vascular endothelial growth factor (VEGF) and its high-affinity receptor, Flt-1 (fms-like tyrosine kinase 1), in bronchoalveolar lavage fluid (BALF) of patients with IPF and pulmonary sarcoidosis. We have also investigated the mRNA expression of angiogenetic chemokines' receptors such as CXCR2 and CXCR3 and the biological axis of stromal derived factor-1 alpha (SDF-1 alpha or CXCL12 alpha/CXCL12 beta) and receptor, CXCR4.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20169144-11295656,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1740-2530
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
2009
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
537929
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pubmed:dateRevised |
2010-9-30
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pubmed:meshHeading |
pubmed-meshheading:20169144-Adult,
pubmed-meshheading:20169144-Aged,
pubmed-meshheading:20169144-Aged, 80 and over,
pubmed-meshheading:20169144-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:20169144-Chemokines, CXC,
pubmed-meshheading:20169144-Female,
pubmed-meshheading:20169144-Humans,
pubmed-meshheading:20169144-Idiopathic Pulmonary Fibrosis,
pubmed-meshheading:20169144-Male,
pubmed-meshheading:20169144-Middle Aged,
pubmed-meshheading:20169144-Prospective Studies,
pubmed-meshheading:20169144-RNA, Messenger,
pubmed-meshheading:20169144-Sarcoidosis, Pulmonary,
pubmed-meshheading:20169144-Vascular Endothelial Growth Factor A,
pubmed-meshheading:20169144-Vascular Endothelial Growth Factor Receptor-1
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pubmed:year |
2009
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pubmed:articleTitle |
Different activity of the biological axis VEGF-Flt-1 (fms-like tyrosine kinase 1) and CXC chemokines between pulmonary sarcoidosis and idiopathic pulmonary fibrosis: a bronchoalveolar lavage study.
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pubmed:affiliation |
Department of Thoracic Medicine, University Hospital, Medical School, University of Crete, Heraklion, 71110 Crete, Greece. katerinaantoniou@yahoo.gr
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pubmed:publicationType |
Journal Article,
Comparative Study
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