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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-4-20
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pubmed:abstractText |
Drug-eluting stents (DESs) reduce neointima area and in-stent restenosis but delay re-endothelialization. Recently, we demonstrated that pharmacological expansion and functional enhancement of endothelial progenitor cells (EPCs) can be achieved by treatment with a glycogen synthase kinase-3beta inhibitor (GSKi)-even for feeble cells derived from coronary artery disease patients. GSKi treatment enhanced EPC adhesion via up-regulated expression of the alpha-4 integrin, ameliorated re-endothelialization, and reduced neointima formation in denuded murine arteries. Hence, we hypothesized that GSKi-coated stents (GSs) will enhance EPC adhesion and attenuate delayed vascular healing associated with rapamycin, a key DES agent.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1755-3245
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
338-45
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:20167573-Animals,
pubmed-meshheading:20167573-Carotid Arteries,
pubmed-meshheading:20167573-Carotid Artery Diseases,
pubmed-meshheading:20167573-Cell Adhesion,
pubmed-meshheading:20167573-Cell Proliferation,
pubmed-meshheading:20167573-Cells, Cultured,
pubmed-meshheading:20167573-Disease Models, Animal,
pubmed-meshheading:20167573-Drug-Eluting Stents,
pubmed-meshheading:20167573-Endothelial Cells,
pubmed-meshheading:20167573-Glycogen Synthase Kinase 3,
pubmed-meshheading:20167573-Humans,
pubmed-meshheading:20167573-Male,
pubmed-meshheading:20167573-Prosthesis Design,
pubmed-meshheading:20167573-Protein Kinase Inhibitors,
pubmed-meshheading:20167573-Rabbits,
pubmed-meshheading:20167573-Sirolimus,
pubmed-meshheading:20167573-Stem Cells,
pubmed-meshheading:20167573-Time Factors
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pubmed:year |
2010
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pubmed:articleTitle |
Delayed re-endothelialization with rapamycin-coated stents is rescued by the addition of a glycogen synthase kinase-3beta inhibitor.
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pubmed:affiliation |
Vascular Biology Laboratory, Division of Cardiology, University of Ottawa Heart Institute, Room H-2263, Ottawa, ON, Canada K1Y4W7.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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