pubmed:abstractText |
This article reviews the medicinal implications of 5-HT(4)R in the peripheral and central nervous systems, based on data from two hundred bibliographic references. An exhaustive compilation of molecules reported to be antagonists or agonists for 5-HT(4)R is presented, including chemical structures, binding properties and pharmacological profiles. In the last part of the review, some key concepts concerning structure-activity relationships are highlighted.
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pubmed:affiliation |
Centre d'Etudes et de Recherche sur le Médicament de Normandie (CERMN) UPRES EA 4258, FR CNRS 3038, Université de Caen, Boulevard Becquerel, 14032 Caen, France. ronan.bureau@unicaen.fr
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