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rdf:type |
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lifeskim:mentions |
umls-concept:C0008059,
umls-concept:C0017337,
umls-concept:C0079466,
umls-concept:C0205210,
umls-concept:C0205419,
umls-concept:C0242643,
umls-concept:C0376622,
umls-concept:C0424295,
umls-concept:C0524528,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1704939,
umls-concept:C1706817,
umls-concept:C1823242,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
2010-2-19
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pubmed:abstractText |
Guanfacine has been shown to reduce hyperactive behaviors in children with attention-deficit/hyperactivity disorder (ADHD) and possibly in children with pervasive developmental disorder (PDD) and hyperactivity. The aim of this exploratory study was to examine whether gene variants encoding the multidrug resistance protein (MDR1 or ABCB1) , a drug transporter at the blood-brain barrier, are associated with variability in the efficacy of guanfacine in children with PDD and hyperactivity.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20166790-10591283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20166790-10716719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20166790-11211365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20166790-11431228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20166790-12469007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20166790-14749689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20166790-1479049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20166790-15319020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20166790-16275814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20166790-16415525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20166790-17069547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20166790-17185560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20166790-18058331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20166790-18182964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20166790-18762709
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1557-8992
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pubmed:author |
pubmed-author:AmanMichael GMG,
pubmed-author:ArnoldL EugeneLE,
pubmed-author:McCrackenJames TJT,
pubmed-author:McDougleChristopher JCJ,
pubmed-author:PoseyDavidD,
pubmed-author:RitzLouiseL,
pubmed-author:ScahillLawrenceL,
pubmed-author:ShiragaSharonS,
pubmed-author:TierneyElaineE,
pubmed-author:VitielloBenedettoB,
pubmed-author:WhelanFionaF
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pubmed:issnType |
Electronic
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pubmed:volume |
20
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1-5
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pubmed:dateRevised |
2011-7-22
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pubmed:meshHeading |
pubmed-meshheading:20166790-Adolescent,
pubmed-meshheading:20166790-Adrenergic alpha-Agonists,
pubmed-meshheading:20166790-Attention Deficit Disorder with Hyperactivity,
pubmed-meshheading:20166790-Child,
pubmed-meshheading:20166790-Child, Preschool,
pubmed-meshheading:20166790-Child Development Disorders, Pervasive,
pubmed-meshheading:20166790-Female,
pubmed-meshheading:20166790-Genetic Variation,
pubmed-meshheading:20166790-Genotype,
pubmed-meshheading:20166790-Guanfacine,
pubmed-meshheading:20166790-Humans,
pubmed-meshheading:20166790-Male,
pubmed-meshheading:20166790-P-Glycoprotein,
pubmed-meshheading:20166790-Polymerase Chain Reaction,
pubmed-meshheading:20166790-Polymorphism, Single Nucleotide,
pubmed-meshheading:20166790-Psychiatric Status Rating Scales,
pubmed-meshheading:20166790-Treatment Outcome
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pubmed:year |
2010
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pubmed:articleTitle |
Possible influence of variant of the P-glycoprotein gene (MDR1/ABCB1) on clinical response to guanfacine in children with pervasive developmental disorders and hyperactivity.
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pubmed:affiliation |
Research Units on Pediatric Psychopharmacology Autism Network, University of California at Los Angeles, Los Angeles, CA 90024-1759, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Multicenter Study
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