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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-4-15
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pubmed:abstractText |
Powerful mediators of programmed cell death, such as apoptosis and autophagy, can contribute to myocyte cell loss during pathological cardiac conditions. Levosimendan has been shown to exert beneficial hemodynamic effects in presence of global myocardial ischemia and heart failure through vasodilatation and increase of cardiac contractility. Recently, the intracoronary administration of a bolus levosimendan was found to exert favourable cardiac anti-stunning effects without lowering arterial pressure, which limits the use of levosimendan mainly in coronary artery disease. Here we tested whether the intracoronary administration of levosimendan can beneficially modulate programmed cell death in acute regional myocardial ischemia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1573-7241
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5-15
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pubmed:meshHeading |
pubmed-meshheading:20162343-Anesthesia,
pubmed-meshheading:20162343-Animals,
pubmed-meshheading:20162343-Apoptosis,
pubmed-meshheading:20162343-Apoptosis Regulatory Proteins,
pubmed-meshheading:20162343-Autophagy,
pubmed-meshheading:20162343-Blood Pressure,
pubmed-meshheading:20162343-Cardiotonic Agents,
pubmed-meshheading:20162343-Coronary Circulation,
pubmed-meshheading:20162343-Cytochromes c,
pubmed-meshheading:20162343-Gene Expression,
pubmed-meshheading:20162343-Heart,
pubmed-meshheading:20162343-Heart Rate,
pubmed-meshheading:20162343-Hydrazones,
pubmed-meshheading:20162343-In Situ Nick-End Labeling,
pubmed-meshheading:20162343-Microtubule-Associated Proteins,
pubmed-meshheading:20162343-Myocardial Ischemia,
pubmed-meshheading:20162343-Myocardium,
pubmed-meshheading:20162343-Necrosis,
pubmed-meshheading:20162343-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:20162343-Pyridazines,
pubmed-meshheading:20162343-Sus scrofa,
pubmed-meshheading:20162343-Venous Pressure,
pubmed-meshheading:20162343-Ventricular Function, Left,
pubmed-meshheading:20162343-bcl-2-Associated X Protein
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pubmed:year |
2010
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pubmed:articleTitle |
Modulation of programmed forms of cell death by intracoronary levosimendan during regional myocardial ischemia in anesthetized pigs.
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pubmed:affiliation |
Department of Clinical and Experimental Medicine, University of East Piedmont "A. Avogadro", Novara, Italy. grossini@med.unipmn.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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