Source:http://linkedlifedata.com/resource/pubmed/id/20161938
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2010-2-17
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| pubmed:abstractText |
Aqueous, ethanolic and hexane extracts of the leaves of Nauclea latifolia (Rubiaceae) were assessed for their fasting blood glucose lowering effect in normoglycaemic and streptozotocin-diabetic rats. Wistar strain albino rats were given different doses of the extracts after 18 hrs fast and their blood glucose measured at 0, 1, 2, 4 and 6 hours after treatment. The aqueous and ethanolic extracts significantly lowered the fasting blood glucose levels of the STZ-diabetic rats in a dose-dependent manner. The highest dose administered (400 mg/kg) lowered the fasting blood glucose of the diabetic rats by 31.7% (aqueous) and 36.1% (ethanolic) extracts. The aqueous extract did not significantly lower the glucose levels of normoglycaemic rats (maximum 6.6%), nor was any significant decrease seen in the rats administered with the hexane (maximum of 4.0% for normoglycaemic and 2.4% for diabetics) extract. The hypoglycaemic and antihyperglycaemic potentials of the aqueous and ethanolic extracts were comparable to that of glibenclamide (1 mg/kg).These results further support the traditional use of the plant in the treatment of diabetes mellitus.
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| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20161938-10075122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20161938-10967463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20161938-11507745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20161938-12065156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20161938-14595595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20161938-14669243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20161938-14692729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20161938-15636168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20161938-2693840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20161938-4241908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20161938-4619047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20161938-7154702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20161938-7587918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20161938-8778502
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
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| pubmed:issn |
0189-6016
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
5
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
201-8
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| pubmed:dateRevised |
2010-9-30
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| pubmed:year |
2008
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| pubmed:articleTitle |
Hypoglycaemic activity of Nauclea latifolia Sm. (Rubiaceae) in experimental animals.
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| pubmed:affiliation |
Department of Biochemistry, University of Maiduguri, Maiduguri, Nigeria. gidabubakar2003@yahoo.com
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| pubmed:publicationType |
Journal Article
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