Source:http://linkedlifedata.com/resource/pubmed/id/20158387
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2010-2-17
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| pubmed:abstractText |
Acrylamide (ACR) and high contents of fat could be found co-existent in many foods processed by high temperature, such as deep-frying and roasting. This study investigated the effect of enhanced fat consumption on deficits of spermatogenesis induced by ACR, and explored potential mechanisms of oxidative damage involved in this pathology in mice. Results show that enhanced feeding of corn oil and pork fat on mice potentiated the decreases of spermatogonia along with mature sperms after treatment of ACR, and that spermatozoa quality is significantly reduced as a result of enhanced feeding of corn oil and pork fat on mice treated with ACR. Moreover, enhanced consumption of corn oil and pork fat potentiated the up-regulation of malondialdehyde (MDA) level in epididymal sperm and cauda epididymides, also up-regulated level of Protein carbonyls (PCOs) in cauda epididymides, of mice after treatment of ACR. Last, enhanced consumption of corn oil and pork fat potentiated the reduced activity of superoxide dismutases (SOD) in epididymal sperm, corpus, and cauda epididymides, also reduced activity of glutathione peroxidase (GPx) in cauda epididymides, of mice treated with ACR. These data suggest that enhanced feeding of corn oil and pork fat on mice potentiates ACR-induced oxidative stress in the epididymis and epididymal sperm and a subsequent effect on spermatogenesis.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acrylamide,
http://linkedlifedata.com/resource/pubmed/chemical/Corn Oil,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Peroxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Malondialdehyde,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase
|
| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
1537-6524
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
20
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
75-81
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| pubmed:meshHeading |
pubmed-meshheading:20158387-Acrylamide,
pubmed-meshheading:20158387-Animals,
pubmed-meshheading:20158387-Corn Oil,
pubmed-meshheading:20158387-Dietary Fats,
pubmed-meshheading:20158387-Epididymis,
pubmed-meshheading:20158387-Glutathione Peroxidase,
pubmed-meshheading:20158387-Kinetics,
pubmed-meshheading:20158387-Male,
pubmed-meshheading:20158387-Malondialdehyde,
pubmed-meshheading:20158387-Meat Products,
pubmed-meshheading:20158387-Mice,
pubmed-meshheading:20158387-Oxidative Stress,
pubmed-meshheading:20158387-Protein Carbonylation,
pubmed-meshheading:20158387-Sperm Count,
pubmed-meshheading:20158387-Sperm Motility,
pubmed-meshheading:20158387-Spermatogenesis,
pubmed-meshheading:20158387-Spermatozoa,
pubmed-meshheading:20158387-Superoxide Dismutase,
pubmed-meshheading:20158387-Swine
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Enhanced fat consumption potentiates acrylamide-induced oxidative stress in epididymis and epididymal sperm and effect spermatogenesis in mice.
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| pubmed:affiliation |
College of Animal Science and Technology, Shanxi Agricultural University, Taigu 030801 Shanxi, PR China. ypzjx@126.com
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|