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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-2-16
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pubmed:abstractText |
Our goal was to investigate the effects of inhibition of transglutaminase 2 (TGase 2) on endotoxin-induced uveitis (EIU) METHODS: EIU was induced in female Lewis rats by single footpad injections of 200 microg of lipopolysaccharide (LPS). TGase 2 inhibitors were administered intraperitoneally 30 minutes before and at the time of LPS administration. Rats were sacrificed 24 hours after injection, and the effects of the TGase 2 inhibitors were evaluated by the number of intraocular inflammatory cells present on histologic sections and by measuring the TGase 2 activity and TGase products in the aqueous humor (AqH). TGase 2 substrates were also assayed in AqH from uveitis patients.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20157411-10722712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20157411-11738475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20157411-11821898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20157411-12368090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20157411-12511595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20157411-15381106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20157411-15471861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20157411-16720373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20157411-16770160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20157411-16809220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20157411-1683928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20157411-2037026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20157411-2858282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20157411-2868387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20157411-4935040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20157411-5965538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20157411-6337969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20157411-6519200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20157411-7402339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20157411-8549947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20157411-9089643
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1011-8942
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
29-34
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pubmed:dateRevised |
2010-9-28
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pubmed:meshHeading |
pubmed-meshheading:20157411-Animals,
pubmed-meshheading:20157411-Disease Progression,
pubmed-meshheading:20157411-Enzyme Inhibitors,
pubmed-meshheading:20157411-Female,
pubmed-meshheading:20157411-GTP-Binding Proteins,
pubmed-meshheading:20157411-Lipopolysaccharides,
pubmed-meshheading:20157411-Rats,
pubmed-meshheading:20157411-Rats, Inbred Lew,
pubmed-meshheading:20157411-Transglutaminases,
pubmed-meshheading:20157411-Uveitis
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pubmed:year |
2010
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pubmed:articleTitle |
A novel therapeutic target in inflammatory uveitis: transglutaminase 2 inhibitor.
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pubmed:affiliation |
Department of Ophthalmology, Hangil Eye Hospital, Incheon, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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