| pubmed-article:2015713 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2015713 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:2015713 | lifeskim:mentions | umls-concept:C0026769 | lld:lifeskim |
| pubmed-article:2015713 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:2015713 | lifeskim:mentions | umls-concept:C0009013 | lld:lifeskim |
| pubmed-article:2015713 | lifeskim:mentions | umls-concept:C0333516 | lld:lifeskim |
| pubmed-article:2015713 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:2015713 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:2015713 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2015713 | pubmed:dateCreated | 1991-5-17 | lld:pubmed |
| pubmed-article:2015713 | pubmed:abstractText | T cell clones derived from cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) were analysed for their ability to produce interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2) and interleukin-4 (IL-4). The CSF-T clones were compared for their ability to produce cytokines with autologous peripheral T clones and with liver-infiltrating T cell clones from patients with chronic active hepatitis. IL-4 production was also compared with that by peripheral T clones derived from atopic patients. All the CSF-T clones (both CD4+ and CD8+) produced large amounts of IFN-gamma and particularly of TNF-alpha. These cytokines were synthesized in significantly larger amounts by CSF T clones than by reference clones. Moreover, they were capable of secreting IL-2, but not IL-4. We conclude that the CSF-CD4+ T clones could constitute a subset with functional properties similar to those of T helper 1 (Th1)inflammatory cells of the mouse; and that the large amounts of TNF produced by CSF T cell clones strongly suggest a significant role for this cytokine in MS immunopathogenesis. | lld:pubmed |
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| pubmed-article:2015713 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2015713 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2015713 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2015713 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2015713 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2015713 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2015713 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2015713 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:2015713 | pubmed:author | pubmed-author:FieschiCC | lld:pubmed |
| pubmed-article:2015713 | pubmed:author | pubmed-author:FrancoAA | lld:pubmed |
| pubmed-article:2015713 | pubmed:author | pubmed-author:BalsanoFF | lld:pubmed |
| pubmed-article:2015713 | pubmed:author | pubmed-author:ParoliMM | lld:pubmed |
| pubmed-article:2015713 | pubmed:author | pubmed-author:BarnabaVV | lld:pubmed |
| pubmed-article:2015713 | pubmed:author | pubmed-author:ButtinelliCC | lld:pubmed |
| pubmed-article:2015713 | pubmed:author | pubmed-author:BenvenutoRR | lld:pubmed |
| pubmed-article:2015713 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2015713 | pubmed:volume | 84 | lld:pubmed |
| pubmed-article:2015713 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2015713 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2015713 | pubmed:pagination | 97-102 | lld:pubmed |
| pubmed-article:2015713 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:2015713 | pubmed:meshHeading | pubmed-meshheading:2015713-... | lld:pubmed |
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| pubmed-article:2015713 | pubmed:meshHeading | pubmed-meshheading:2015713-... | lld:pubmed |
| pubmed-article:2015713 | pubmed:meshHeading | pubmed-meshheading:2015713-... | lld:pubmed |
| pubmed-article:2015713 | pubmed:meshHeading | pubmed-meshheading:2015713-... | lld:pubmed |
| pubmed-article:2015713 | pubmed:meshHeading | pubmed-meshheading:2015713-... | lld:pubmed |
| pubmed-article:2015713 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:2015713 | pubmed:articleTitle | Tumour necrosis factor-alpha synthesis by cerebrospinal-fluid-derived T cell clones from patients with multiple sclerosis. | lld:pubmed |
| pubmed-article:2015713 | pubmed:affiliation | Fondazione Andrea Cesalpino, I Clinica Medica, Università La Sapienza, Rome, Italy. | lld:pubmed |
| pubmed-article:2015713 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2015713 | pubmed:publicationType | Comparative Study | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2015713 | lld:pubmed |
