Linked Life Data

2015713

Source:http://linkedlifedata.com/resource/pubmed/id/2015713

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-5-17
pubmed:abstractText
T cell clones derived from cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) were analysed for their ability to produce interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2) and interleukin-4 (IL-4). The CSF-T clones were compared for their ability to produce cytokines with autologous peripheral T clones and with liver-infiltrating T cell clones from patients with chronic active hepatitis. IL-4 production was also compared with that by peripheral T clones derived from atopic patients. All the CSF-T clones (both CD4+ and CD8+) produced large amounts of IFN-gamma and particularly of TNF-alpha. These cytokines were synthesized in significantly larger amounts by CSF T clones than by reference clones. Moreover, they were capable of secreting IL-2, but not IL-4. We conclude that the CSF-CD4+ T clones could constitute a subset with functional properties similar to those of T helper 1 (Th1)inflammatory cells of the mouse; and that the large amounts of TNF produced by CSF T cell clones strongly suggest a significant role for this cytokine in MS immunopathogenesis.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-14313512, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-1693015, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-1968485, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-2212948, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-2302841, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-2416267, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-2419430, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-2419764, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-2427582, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-2455603, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-2456857, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-2468787, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-2472442, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-2472810, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-2477450, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-2523712, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-2541163, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-2555395, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-2754393, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-2797205, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-2882294, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-2908229, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-2931449, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-2942317, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-2946956, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-2960769, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-2967331, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-2969394, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-2969818, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-2985995, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-2997627, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-3008003, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-3010124, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-3040886, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-3092113, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-3115791, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-3116087, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-312620, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-3132537, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-3132891, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-3146861, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-3258624, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-3936865, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-3941297, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-6198590, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-6210303, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-6433204, http://linkedlifedata.com/resource/pubmed/commentcorrection/2015713-6750404
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0009-9104
pubmed:author
pubmed:issnType
Print
pubmed:volume
84
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
97-102
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Tumour necrosis factor-alpha synthesis by cerebrospinal-fluid-derived T cell clones from patients with multiple sclerosis.
pubmed:affiliation
Fondazione Andrea Cesalpino, I Clinica Medica, Università La Sapienza, Rome, Italy.
pubmed:publicationType
Journal Article, Comparative Study