Source:http://linkedlifedata.com/resource/pubmed/id/20156840
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
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| pubmed:dateCreated |
2010-10-11
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| pubmed:abstractText |
The L1 adhesion molecule functions in axon growth and guidance, but a role in synaptic development of cortical inhibitory interneurons is largely unexplored. L1 mediates adhesion by engaging the actin cytoskeleton through binding the actin/spectrin adapter protein ankyrin. Loss of L1-ankyrin interaction impaired process elaboration/branching by GABAergic interneurons, including basket cells, and reduced the number of perisomatic synapses in the cingulate cortex as shown in L1 mutant mice (L1YH) with a mutation in the ankyrin-binding site, either alone or intercrossed with GAD67-enhanced green fluorescence protein reporter mice. Electron microscopy revealed that perisomatic inhibitory synapses but not excitatory synapses in the neuropil were specifically affected. In wild-type cingulate cortex, L1 colocalized with perisomatic synaptic markers, whereas L1 phosphorylation on Tyr(1229) decreased postnatally, correlating with increased ankyrin binding and synaptic development. These results suggest a novel role for L1 engagement with the actin cytoskeleton in development of inhibitory connectivity within the cingulate cortex.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
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| pubmed:issn |
1460-2199
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
20
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2684-93
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:20156840-Actin Cytoskeleton,
pubmed-meshheading:20156840-Animals,
pubmed-meshheading:20156840-Ankyrins,
pubmed-meshheading:20156840-Gene Knock-In Techniques,
pubmed-meshheading:20156840-Gyrus Cinguli,
pubmed-meshheading:20156840-Interneurons,
pubmed-meshheading:20156840-Male,
pubmed-meshheading:20156840-Mice,
pubmed-meshheading:20156840-Mice, Neurologic Mutants,
pubmed-meshheading:20156840-Mice, Transgenic,
pubmed-meshheading:20156840-Neocortex,
pubmed-meshheading:20156840-Neural Cell Adhesion Molecule L1,
pubmed-meshheading:20156840-Neural Inhibition,
pubmed-meshheading:20156840-Prefrontal Cortex,
pubmed-meshheading:20156840-Presynaptic Terminals,
pubmed-meshheading:20156840-Protein Binding,
pubmed-meshheading:20156840-Synapses,
pubmed-meshheading:20156840-gamma-Aminobutyric Acid
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| pubmed:year |
2010
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| pubmed:articleTitle |
Perisomatic GABAergic innervation in prefrontal cortex is regulated by ankyrin interaction with the L1 cell adhesion molecule.
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| pubmed:affiliation |
Department of Biochemistry, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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