| pubmed-article:2015626 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2015626 | lifeskim:mentions | umls-concept:C0015576 | lld:lifeskim |
| pubmed-article:2015626 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:2015626 | lifeskim:mentions | umls-concept:C0033681 | lld:lifeskim |
| pubmed-article:2015626 | lifeskim:mentions | umls-concept:C1514762 | lld:lifeskim |
| pubmed-article:2015626 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:2015626 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2015626 | pubmed:dateCreated | 1991-5-23 | lld:pubmed |
| pubmed-article:2015626 | pubmed:abstractText | Engagement of the clonotypic antigen receptor (TCR) on T lymphocytes provokes an activation response leading to cell proliferation and lymphokine secretion. To examine the molecular basis of T cell signaling, we generated transgenic animals in which a lymphocyte-specific nonreceptor protein-tyrosine kinase p59fyn(T) is 20-fold overexpressed in developing T lineage cells. Thymocytes from these mice, analyzed using both cellular and biochemical assays, were remarkably hyperstimulable. Moreover, the responsiveness of normal thymocytes to TCR-derived signals correlated well with the extent to which p59fyn was expressed in these cells. Overexpression of a catalytically inactive form of p59fyn substantially inhibited TCR-mediated activation in otherwise normal thymocytes. These effects are unique to p59fyn; overexpression of a closely related T cell-specific tyrosine kinase, p56lck, elicits dramatically different phenotypes. Our results suggest that p59fyn is a critically important component of the TCR signal transduction apparatus. | lld:pubmed |
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| pubmed-article:2015626 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2015626 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2015626 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2015626 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2015626 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2015626 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:2015626 | pubmed:author | pubmed-author:PerlmutterR... | lld:pubmed |
| pubmed-article:2015626 | pubmed:author | pubmed-author:CookeM PMP | lld:pubmed |
| pubmed-article:2015626 | pubmed:author | pubmed-author:AbrahamK MKM | lld:pubmed |
| pubmed-article:2015626 | pubmed:author | pubmed-author:ForbushK AKA | lld:pubmed |
| pubmed-article:2015626 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2015626 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:2015626 | pubmed:volume | 65 | lld:pubmed |
| pubmed-article:2015626 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2015626 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2015626 | pubmed:pagination | 281-91 | lld:pubmed |
| pubmed-article:2015626 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:2015626 | pubmed:meshHeading | pubmed-meshheading:2015626-... | lld:pubmed |
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| pubmed-article:2015626 | pubmed:meshHeading | pubmed-meshheading:2015626-... | lld:pubmed |
| pubmed-article:2015626 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:2015626 | pubmed:articleTitle | Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn). | lld:pubmed |
| pubmed-article:2015626 | pubmed:affiliation | Howard Hughes Medical Institute, University of Washington, Seattle 98195. | lld:pubmed |
| pubmed-article:2015626 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2015626 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| entrez-gene:14360 | entrezgene:pubmed | pubmed-article:2015626 | lld:entrezgene |
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