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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-2-19
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pubmed:databankReference |
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pubmed:abstractText |
Combination antiretroviral therapy suppresses but does not eradicate human immunodeficiency virus type 1 (HIV-1) in infected persons, and low-level viremia can be detected despite years of suppressive antiretroviral therapy. Short-course (28-day) intensification of standard antiretroviral combination therapy is a useful approach to determine whether complete rounds of HIV-1 replication in rapidly cycling cells contribute to persistent viremia. We investigated whether intensification with the integrase inhibitor raltegravir decreases plasma HIV-1 RNA levels in patients receiving suppressive antiretroviral therapy.
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pubmed:grant |
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pubmed:commentsCorrections |
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http://linkedlifedata.com/resource/pubmed/commentcorrection/20156060-9371822
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1537-6591
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pubmed:author |
pubmed-author:AcostaEE,
pubmed-author:CoffinJ MJM,
pubmed-author:GarinN DND,
pubmed-author:JonesJJ,
pubmed-author:KearneyMM,
pubmed-author:MaldarelliFF,
pubmed-author:McMahonDD,
pubmed-author:McNultySS,
pubmed-author:MellorsJ WJW,
pubmed-author:MetcalfJ AJA,
pubmed-author:PalmerSS,
pubmed-author:RehnBB,
pubmed-author:WiegandAA
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
912-9
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pubmed:dateRevised |
2011-7-26
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pubmed:meshHeading |
pubmed-meshheading:20156060-Adult,
pubmed-meshheading:20156060-Aged,
pubmed-meshheading:20156060-Anti-HIV Agents,
pubmed-meshheading:20156060-Antiretroviral Therapy, Highly Active,
pubmed-meshheading:20156060-Female,
pubmed-meshheading:20156060-HIV Infections,
pubmed-meshheading:20156060-HIV-1,
pubmed-meshheading:20156060-Humans,
pubmed-meshheading:20156060-Male,
pubmed-meshheading:20156060-Middle Aged,
pubmed-meshheading:20156060-Pyrrolidinones,
pubmed-meshheading:20156060-RNA, Viral,
pubmed-meshheading:20156060-Viral Load,
pubmed-meshheading:20156060-Viremia
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pubmed:year |
2010
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pubmed:articleTitle |
Short-course raltegravir intensification does not reduce persistent low-level viremia in patients with HIV-1 suppression during receipt of combination antiretroviral therapy.
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pubmed:affiliation |
Department of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
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pubmed:publicationType |
Journal Article
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