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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2010-5-12
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pubmed:abstractText |
Previous studies have shown the influence of subchondral bone osteoblasts (SBOs) on phenotypical changes of articular cartilage chondrocytes (ACCs) during the development of osteoarthritis (OA). The molecular mechanisms involved during this process remain elusive, in particular, the signal transduction pathways. The aim of this study was to investigate the in vitro effects of OA SBOs on the phenotypical changes in normal ACCs and to unveil the potential involvement of MAPK signaling pathways during this process.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkaline Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type X,
http://linkedlifedata.com/resource/pubmed/chemical/Core Binding Factor Alpha 1 Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media, Conditioned,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/PD 98059,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1529-0131
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1349-60
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pubmed:meshHeading |
pubmed-meshheading:20155832-Adult,
pubmed-meshheading:20155832-Aged,
pubmed-meshheading:20155832-Alkaline Phosphatase,
pubmed-meshheading:20155832-Cartilage, Articular,
pubmed-meshheading:20155832-Cell Communication,
pubmed-meshheading:20155832-Cell Differentiation,
pubmed-meshheading:20155832-Cells, Cultured,
pubmed-meshheading:20155832-Chondrocytes,
pubmed-meshheading:20155832-Coculture Techniques,
pubmed-meshheading:20155832-Collagen Type X,
pubmed-meshheading:20155832-Core Binding Factor Alpha 1 Subunit,
pubmed-meshheading:20155832-Culture Media, Conditioned,
pubmed-meshheading:20155832-Enzyme Inhibitors,
pubmed-meshheading:20155832-Flavonoids,
pubmed-meshheading:20155832-Humans,
pubmed-meshheading:20155832-Hypertrophy,
pubmed-meshheading:20155832-MAP Kinase Signaling System,
pubmed-meshheading:20155832-Middle Aged,
pubmed-meshheading:20155832-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:20155832-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:20155832-Osteoarthritis,
pubmed-meshheading:20155832-Osteoblasts,
pubmed-meshheading:20155832-Phosphorylation,
pubmed-meshheading:20155832-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2010
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pubmed:articleTitle |
ERK-1/2 and p38 in the regulation of hypertrophic changes of normal articular cartilage chondrocytes induced by osteoarthritic subchondral osteoblasts.
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pubmed:affiliation |
Queensland University of Technology, Brisbane, Queensland, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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