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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-3-25
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pubmed:abstractText |
Indirect acute lung injury is associated with high morbidity and mortality. However, the underlying pathophysiology is only marginally understood, and so far no pathophysiologic-based remedy exists. We hypothesized that apoptosis of lung epithelial cells is a pathophysiological relevant process in the development of indirect acute lung injury and that it should be accessible to a siRNA-based therapeutic intervention in vivo.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1530-0293
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1179-86
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pubmed:dateRevised |
2010-12-3
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pubmed:meshHeading |
pubmed-meshheading:20154604-Acute Lung Injury,
pubmed-meshheading:20154604-Animals,
pubmed-meshheading:20154604-Apoptosis,
pubmed-meshheading:20154604-Blotting, Western,
pubmed-meshheading:20154604-Caspase 3,
pubmed-meshheading:20154604-Cytokines,
pubmed-meshheading:20154604-Disease Models, Animal,
pubmed-meshheading:20154604-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:20154604-In Situ Nick-End Labeling,
pubmed-meshheading:20154604-Lung,
pubmed-meshheading:20154604-Male,
pubmed-meshheading:20154604-Mice,
pubmed-meshheading:20154604-Mice, Inbred C3H,
pubmed-meshheading:20154604-Mice, Knockout,
pubmed-meshheading:20154604-Polymerase Chain Reaction
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pubmed:year |
2010
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pubmed:articleTitle |
Therapeutic accessibility of caspase-mediated cell death as a key pathomechanism in indirect acute lung injury.
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pubmed:affiliation |
Shock-Trauma Research Laboratories in the Division of Surgical Research and Department of Surgery, Rhode Island Hospital and Brown University, School of Medicine, Providence, RI, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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