20154404

Source:http://linkedlifedata.com/resource/pubmed/id/20154404

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0003591, umls-concept:C0009429, umls-concept:C0026809, umls-concept:C0332161, umls-concept:C0556895, umls-concept:C0753287, umls-concept:C0871261, umls-concept:C1098320, umls-concept:C1704632, umls-concept:C1706817, umls-concept:C2911692
pubmed:issue	4
pubmed:dateCreated	2010-3-26
pubmed:abstractText	The endothelium modulates vascular tone by synthesizing and releasing several vasodilating factors, including vasodilator prostaglandins, nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF). In the present study, we examined whether an angiotensin-receptor blocker, a calcium-channel blocker or their combination improved EDHF-mediated responses in diabetic apolipoprotein E-deficient (ApoE(-/-)) mice.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101137683
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II Type 1 Receptor..., http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins E, http://linkedlifedata.com/resource/pubmed/chemical/Azetidinecarboxylic Acid, http://linkedlifedata.com/resource/pubmed/chemical/Biological Factors, http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Blockers, http://linkedlifedata.com/resource/pubmed/chemical/Dihydropyridines, http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles, http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type III, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt, http://linkedlifedata.com/resource/pubmed/chemical/Streptozocin, http://linkedlifedata.com/resource/pubmed/chemical/Tetrazoles, http://linkedlifedata.com/resource/pubmed/chemical/azelnidipine, http://linkedlifedata.com/resource/pubmed/chemical/endothelium-dependent..., http://linkedlifedata.com/resource/pubmed/chemical/olmesartan
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	1347-4820
pubmed:author	pubmed-author:HosoyaMakiM, pubmed-author:OhashiJunkoJ, pubmed-author:SawadaAyukoA, pubmed-author:ShimokawaHiroakiH, pubmed-author:TakakiAyaA
pubmed:issnType	Electronic
pubmed:volume	74
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	798-806
pubmed:dateRevised	2011-2-18
pubmed:meshHeading	pubmed-meshheading:20154404-Angiotensin II Type 1 Receptor Blockers, pubmed-meshheading:20154404-Animals, pubmed-meshheading:20154404-Apolipoproteins E, pubmed-meshheading:20154404-Azetidinecarboxylic Acid, pubmed-meshheading:20154404-Biological Factors, pubmed-meshheading:20154404-Calcium Channel Blockers, pubmed-meshheading:20154404-Diabetes Mellitus, Experimental, pubmed-meshheading:20154404-Dihydropyridines, pubmed-meshheading:20154404-Disease Models, Animal, pubmed-meshheading:20154404-Drug Therapy, Combination, pubmed-meshheading:20154404-Endothelium, Vascular, pubmed-meshheading:20154404-Imidazoles, pubmed-meshheading:20154404-Male, pubmed-meshheading:20154404-Mice, pubmed-meshheading:20154404-Mice, Inbred C57BL, pubmed-meshheading:20154404-Mice, Knockout, pubmed-meshheading:20154404-Nitric Oxide Synthase Type III, pubmed-meshheading:20154404-Proto-Oncogene Proteins c-akt, pubmed-meshheading:20154404-Signal Transduction, pubmed-meshheading:20154404-Streptozocin, pubmed-meshheading:20154404-Tetrazoles, pubmed-meshheading:20154404-Vasodilation
pubmed:year	2010
pubmed:articleTitle	Combination therapy with olmesartan and azelnidipine improves EDHF-mediated responses in diabetic apolipoprotein E-deficient mice.
pubmed:affiliation	Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't