| pubmed-article:2015423 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2015423 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:2015423 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:2015423 | lifeskim:mentions | umls-concept:C0004811 | lld:lifeskim |
| pubmed-article:2015423 | lifeskim:mentions | umls-concept:C0033634 | lld:lifeskim |
| pubmed-article:2015423 | lifeskim:mentions | umls-concept:C1155937 | lld:lifeskim |
| pubmed-article:2015423 | lifeskim:mentions | umls-concept:C0043791 | lld:lifeskim |
| pubmed-article:2015423 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2015423 | pubmed:dateCreated | 1991-5-23 | lld:pubmed |
| pubmed-article:2015423 | pubmed:abstractText | 1. 5-Hydroxytryptamine (5-HT) produced a concentration-dependent increase in the membrane concentration of 1,2-diacylglycerol (DG) in the rabbit isolated basilar artery, but did not stimulate the hydrolysis of membrane phosphoinositide. 2. The 5-HT-induced accumulation of DG could be blocked with the putative phospholipase C inhibitor 2-nitro-4-carboxyphenyl-N,N-diphenylcarbamate (NCDC; 70 microM), but not with the protein kinase C inhibitor, 1-(5-isoquinolinesulphonyl)-2-methyl piperazine (H7; 50 microM). 3. Direct stimulation of protein kinase C with phorbol 12,13-dibutyrate (PDBu) produced sustained smooth muscle contraction which was fairly rapid in onset and could be reversed by H7 but not by NCDC. The inactive phorbol, 4 alpha phorbol 12,13-dideceonate, did not produce contraction in the basilar artery. 4. 5-HT-induced contractions (1 nM-100 microM) were blocked or greatly reduced in the presence of the protein kinase inhibitor H7 or polymyxin B, and with the phospholipase C inhibitor, NCDC. The concentrations of these inhibitors which abolished contraction to 5-HT, did not alter smooth muscle contraction produced in response to 30 mM K(+)-physiological salt solution (PSS). 5. These data suggest that DG production and the subsequent activation of PKC forms an important component of the cerebrovascular contractile response to 5-HT. As the DG does not appear to arise from membrane phosphatidylinositol, it appears that 5-HT can stimulate the production of this second messenger in cerebral arteries by a mechanism which is different from peripheral arteries. | lld:pubmed |
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| pubmed-article:2015423 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2015423 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2015423 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2015423 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2015423 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2015423 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:2015423 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:2015423 | pubmed:author | pubmed-author:ClarkA HAH | lld:pubmed |
| pubmed-article:2015423 | pubmed:author | pubmed-author:GarlandC JCJ | lld:pubmed |
| pubmed-article:2015423 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2015423 | pubmed:volume | 102 | lld:pubmed |
| pubmed-article:2015423 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2015423 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2015423 | pubmed:pagination | 415-21 | lld:pubmed |
| pubmed-article:2015423 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:2015423 | pubmed:meshHeading | pubmed-meshheading:2015423-... | lld:pubmed |
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| pubmed-article:2015423 | pubmed:meshHeading | pubmed-meshheading:2015423-... | lld:pubmed |
| pubmed-article:2015423 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:2015423 | pubmed:articleTitle | 5-hydroxytryptamine-stimulated accumulation of 1,2-diacylglycerol in the rabbit basilar artery: a role for protein kinase C in smooth muscle contraction. | lld:pubmed |
| pubmed-article:2015423 | pubmed:affiliation | Department of Physiology and Pharmacology, University of Southampton. | lld:pubmed |
| pubmed-article:2015423 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2015423 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2015423 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2015423 | lld:pubmed |
